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Review
. 2022 Feb 24;27(5):1534.
doi: 10.3390/molecules27051534.

The Current Directions of Searching for Antiparasitic Drugs

Katarzyna Dziduch  1 , Dominika Greniuk  1 , Monika Wujec  1
Affiliations
Review

The Current Directions of Searching for Antiparasitic Drugs

Katarzyna Dziduch et al. Molecules. .

Abstract

Parasitic diseases are still a huge problem for mankind. They are becoming the main cause of chronic diseases in the world. Migration of the population, pollution of the natural environment, and climate changes cause the rapid spread of diseases. Additionally, a growing resistance of parasites to drugs is observed. Many research groups are looking for effective antiparasitic drugs with low side effects. In this work, we present the current trends in the search for antiparasitic drugs. We report known drugs used in other disease entities with proven antiparasitic activity and research on new chemical structures that may be potential drugs in parasitic diseases. The described investigations of antiparasitic compounds can be helpful for further drug development.

Keywords: antiparasitic activity; drugs; new chemical compounds.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The structure of amioder.
Figure 2
Figure 2
The structures of benzoxaborole analogs of flubendazole.
Figure 3
Figure 3
The structures of benzoxaborole analogs with indole moiety.
Figure 4
Figure 4
The structures of benzimidazole derivatives.
Figure 5
Figure 5
The structures of new analogs of bisnaphthalimidopropyl.
Figure 6
Figure 6
The structures of the three most active aurone analogs.
Figure 7
Figure 7
The structure of 2-amino-5,10-dihydro-5,10-dioxo-4-(2,3,4,5,6-pentafluorophenyl)-4H-naphtho[2,3-b]pyran-3-carbonitrile.
Figure 8
Figure 8
The structure of the new active derivative of naphthoquinone.
Figure 9
Figure 9
The structure of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles.
Figure 10
Figure 10
The structure of furanyl-N-acylhydrazone derivatives.
Figure 11
Figure 11
The structure of new thiazolidin-4-one derivatives.
Figure 12
Figure 12
The structure of previously reported conjugates (I,II) and new conjugates (III–V).
Figure 12
Figure 12
The structure of previously reported conjugates (I,II) and new conjugates (III–V).
Figure 13
Figure 13
The structural formula of miltefosine.
Figure 14
Figure 14
The structure of potential inhibitors of protozoan metacaspases.
Figure 15
Figure 15
The structure of 1,3,4-thiadiazole derivatives.
Figure 16
Figure 16
The structure of thiazole derivatives.
Figure 17
Figure 17
The structure of 2,4-diaminotriazine-thiazole derivatives.
Figure 18
Figure 18
The structure of 1-(4-methylimidazol-5-oyl)-4-substituted thiosemicarbazide.
Figure 19
Figure 19
The structure of 1-(1-methyl-4-nitroimidazol-2-oyl)-4-substituted thiosemicarbazide.
Figure 20
Figure 20
The structure of 1-cyclopentanoyl-4-(3-iodophenyl)thiosemicarbazide.
See this image and copyright information in PMC

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