Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Mar 4;11(5):889.
doi: 10.3390/cells11050889.

Revealing the Roles of MOAP1 in Diseases: A Review

Yanfang Su  1 , Weixia Wang  1 , Xianfang Meng  1
Affiliations
Review

Revealing the Roles of MOAP1 in Diseases: A Review

Yanfang Su et al. Cells. .

Abstract

Modulator of apoptosis protein1 (MOAP1), also known as MAP1 and PNMA4, belongs to the PNMA gene family consisting of at least 15 genes located on different chromosomes. MOAP1 interacts with the BAX protein, one of the most important apoptosis regulators. Due to its critical role in a few of disease-associated pathways, MOAP1 is associated with many diseases such as cancers and neurological diseases. In this study, we introduced MOAP1 and its biological functions and reviewed the associations between MOAP1 and a few diseases including cancers, neurological diseases, and other diseases such as inflammation and heart diseases. We also explained possible biological mechanisms underlying the associations between MOAP1 and these diseases, and discussed a few future directions regarding MOAP1, especially its potential roles in neurodegenerative disorders. In summary, MOAP1 plays a critical role in the development and progression of cancers and neurological diseases by regulating a few genes related to cellular apoptosis such as BAX and RASSF1A and interacting with disease-associated miRNAs, including miR-25 and miR1228.

Keywords: MOAP1; apoptosis; biomarker; cancer; neurodegenerative diseases.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The common functions of MOAP1 and its related diseases.
Figure 2
Figure 2
MOAP1 acts as a modulator on cancer-associated miRNAs and cancers.
Figure 3
Figure 3
MOAP1 interacts with other genes to perform cancer-related functions and the literature supporting the interactions and functions.
See this image and copyright information in PMC

References

    1. Pang S.W., Lahiri C., Poh C.L., Tan K.O. PNMA family: Protein interaction network and cell signalling pathways implicated in cancer and apoptosis. Cell Signal. 2018;45:54–62. doi: 10.1016/j.cellsig.2018.01.022. - DOI - PubMed
    1. Tan K., Tan K., Chan S.L., Yee K.S.Y., Bévort M., Ang K., Yu V. MAP-1, a Novel Proapoptotic Protein Containing a BH3-like Motif That Associates with Bax through Its Bcl-2 Homology Domains. J. Biol. Chem. 2001;276:2802–2807. doi: 10.1074/jbc.M008955200. - DOI - PubMed
    1. Vos M.D., Dallol A., Eckfeld K., Allen N.P., Donninger H., Hesson L.B., Calvisi D., Latif F., Clark G.J. The RASSF1A tumor suppressor activates Bax via MOAP-1. J. Biol. Chem. 2006;281:4557–4563. doi: 10.1074/jbc.M512128200. - DOI - PubMed
    1. Hertz C.E., Bayarri-Olmos R., Kirketerp-Moller N., van Putten S., Pilely K., Skjoedt M.O., Garred P. Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities. Front. Immunol. 2018;9:1945. doi: 10.3389/fimmu.2018.01945. - DOI - PMC - PubMed
    1. Tan C.T., Zhou Q.L., Su Y.C., Fu N.Y., Chang H.C., Tao R.N., Sukumaran S.K., Baksh S., Tan Y.J., Sabapathy K., et al. MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria. Cell Rep. 2016;16:174–185. doi: 10.1016/j.celrep.2016.05.068. - DOI - PubMed

Publication types

MeSH terms