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Review
. 2022 Feb 28;23(5):2701.
doi: 10.3390/ijms23052701.

Age Related Osteoporosis: Targeting Cellular Senescence

Ursula Föger-Samwald  1 , Katharina Kerschan-Schindl  2 , Maria Butylina  3 , Peter Pietschmann  3
Affiliations
Review

Age Related Osteoporosis: Targeting Cellular Senescence

Ursula Föger-Samwald et al. Int J Mol Sci. .

Abstract

Age-related chronic diseases are an enormous burden to modern societies worldwide. Among these, osteoporosis, a condition that predisposes individuals to an increased risk of fractures, substantially contributes to increased mortality and health-care costs in elderly. It is now well accepted that advanced chronical age is one of the main risk factors for chronical diseases. Hence, targeting fundamental aging mechanisms such as senescence has become a promising option in the treatment of these diseases. Moreover, for osteoporosis, the main pathophysiological concepts arise from menopause causing estrogen deficiency, and from aging. Here, we focus on recent advances in the understanding of senescence-related mechanisms contributing to age-related bone loss. Furthermore, treatment options for senile osteoporosis targeting senescent cells are reviewed.

Keywords: age-related osteoporosis; cellular senescence; osteoporosis therapy.

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Conflict of interest statement

Katharina Kerschan-Schindl has received research support and/or remuneration from Amgen GmbH, Lilly GmbH, Merck, Sharp and Dohme GmbH, Stada GmbH, Roche Austria, and Servier Austria. Peter Pietschmann has received research support and/or honoraria from Amgen GmbH, Biomedica GmbH, DePuySynthes, Eli Lilly GmbH, Fresenius Kabi Austria, Meda Pharma/Mylan GmbH, Shire Austria GmbH, TAmiRNA GmbH, and UCB Biopharma Srl/UCB Pharma. All other authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
(A) Toluidine blue staining of a mouse femur showing osteoblasts (arrows) and osteocytes (triangles) (female, 8 weeks of age, original magnification 400×). (B) TRAP and toluidine blue staining of a mouse tibia, showing bone lining cells (arrows) and osteocytes (triangles) (female, 18 weeks of age, original magnification 400×).
Figure 2
Figure 2
TRAP and toluidine blue staining of a Sprague-Dawley rat tibia, showing osteoclasts with positive TRAP staining (arrows) (female, 10–12 weeks of age, original magnification 400×).
See this image and copyright information in PMC

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