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Review
. 2022 Mar 3;23(5):2805.
doi: 10.3390/ijms23052805.

miRNAs in Cancer (Review of Literature)

Beata Smolarz  1 , Adam Durczyński  2 , Hanna Romanowicz  1 , Krzysztof Szyłło  3 , Piotr Hogendorf  2
Affiliations
Review

miRNAs in Cancer (Review of Literature)

Beata Smolarz et al. Int J Mol Sci. .

Abstract

MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the course of processes of fundamental importance for the proper functioning of the organism. These processes include cell division, proliferation, differentiation, cell apoptosis and the formation of blood vessels. Altered expression of individual miRNAs has been shown in numerous cancers, which may indicate the oncogenic or suppressor potential of the molecules in question. This paper discusses the current knowledge about the possibility of using miRNA as a diagnostic marker and a potential target in modern anticancer therapies.

Keywords: cancer; diagnosis; miRNA.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Suppressor miRNA.
Figure 2
Figure 2
Circulating microRNAs as potential cancer biomarkers (the arrow indicates the expression level).
Figure 3
Figure 3
Schematic compilation of anticancer strategies using miRNA.
Figure 4
Figure 4
RNA aptamers in the treatment of cancer [170,171,172,173].
See this image and copyright information in PMC

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