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Comment
. 2022 Mar 9;30(3):277-278.
doi: 10.1016/j.chom.2022.02.009.

Fungi make fun guys

Sarah L Gaffen  1 , Partha S Biswas  2
Affiliations
Comment

Fungi make fun guys

Sarah L Gaffen et al. Cell Host Microbe. .

Abstract

In a recent Cell study, Leonardi et al. show that commensal mucosa-associated gut fungi profoundly impact host immunity, epithelial barrier function, and, unexpectedly, neuroimmune modulation of social behavior. All of these events are controlled by fungal-induced activation of type 17 cytokines that act on both epithelial cells and neurons.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Fig 1:
Fig 1:. Spatial organization of gut microbiota influence immunity, epithelial barrier function and social behavior in mice.
Sequencing of ribosomal DNA on luminal and mucosal fungi identified diverse luminal fungal communities but comparatively less diverse mucosa-associated fungal (MAF) communities in the gut. MAF but not luminal fungi could promote barrier function through induction of Type 17 cytokines (IL-22 and IL-17) by CD4+ T cells, which protect mice against DSS-induced intestinal epithelial injury and also Citrobacter rodentium bacterial infection. MAF also influences neuroimmune modulation of mouse social behavior by virtue of IL-17 receptor signaling in neurons. Image created with BioRender.com. Images of mice was purchased from ©www.gograph.com / Kudryashka.
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