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Review
. 2022 Aug;35(4):429-434.
doi: 10.1016/j.jpag.2022.02.002. Epub 2022 Mar 8.

The Care of Adolescents and Young Adults with Turner Syndrome: A Pediatric and Adolescent Gynecology Perspective

Tazim Dowlut-McElroy  1 , Roopa Kanakatti Shankar  2
Affiliations
Review

The Care of Adolescents and Young Adults with Turner Syndrome: A Pediatric and Adolescent Gynecology Perspective

Tazim Dowlut-McElroy et al. J Pediatr Adolesc Gynecol. 2022 Aug.

Abstract

Turner syndrome (TS) is caused by the absence of a part or whole X chromosome in a phenotypic female and has an estimated prevalence of 25-50/100,000 live-born females. The primary gynecologic manifestation of TS is primary ovarian insufficiency (POI), and the resulting hypoestrogenism and infertility are experienced by most individuals with TS. In this review, we summarize the recommendations for the care of adolescents and young adults with TS, with a focus on primary ovarian insufficiency in TS, hormone replacement therapy, fertility preservation, and pregnancy in TS.

Keywords: DSD; Fertility; Hormone replacement therapy; POI; Pregnancy complications; Preservation; Pubertal induction; Turner syndrome.

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Conflict of interest statement

Conflict of Interest/Disclosure Statement

The authors report no proprietary or commercial interest in any product mentioned or concept discussed in this article.

Figures

Figure 1:
Figure 1:
Practical Approach to incremental Hormone replacement for Pubertal induction in Turner Syndrome
See this image and copyright information in PMC

References

    1. Gravholt CH, Andersen NH, Conway GS, et al. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. Eur J Endocrinol. 2017;177(3):G1–G70. - PubMed
    1. Klein KO, Rosenfield RL, Santen RJ, et al. Estrogen Replacement in Turner Syndrome: Literature Review and Practical Considerations. J Clin Endocrinol Metab. 2018;103(5):1790–1803. - PubMed
    1. Classic pages in obstetrics and gynecology by Henry H. Turner. A syndrome of infantilism, congenital webbed neck, and cubitus valgus. Endocrinology, vol. 23, pp. 566-574, 1938. Am J Obstet Gynecol. 1972;113(2):279. - PubMed
    1. Singh RP, Carr DH. The anatomy and histology of XO human embryos and fetuses. Anat Rec. 1966;155(3):369–383. - PubMed
    1. Modi DN, Sane S, Bhartiya D. Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads. Mol Hum Reprod. 2003;9(4):219–225. - PubMed