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Case Reports
. 2022 May-Jun;97(3):321-325.
doi: 10.1016/j.abd.2021.03.012. Epub 2022 Mar 7.

Hand, foot, and mouth disease in adults caused by Coxsackievirus B1-B6

Anama Di Prinzio  1 , Dolores Pilar Bastard  1 , Ana Clara Torre  2 , Luis Daniel Mazzuoccolo  1
Affiliations
Case Reports

Hand, foot, and mouth disease in adults caused by Coxsackievirus B1-B6

Anama Di Prinzio et al. An Bras Dermatol. 2022 May-Jun.

Abstract

Hand, foot, and mouth disease is a viral rickettsial disease caused by Coxsackievirus A16 and Enterovirus 71 in most cases. It is commonly seen in children under ten years old, who present oral enanthema and a macular, maculopapular, or vesicular rash on their hands and feet. However, an increase in cases caused by other viral serotypes was observed in adults in recent years with various clinical presentations and a troublesome diagnosis. Three cases of hand, foot, and mouth disease are reported to show the clinical variability and diagnostic complexity that this disease may present in adult patients.

Keywords: Adults; Enterovirus; Hand, foot and mouth disease.

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Figures

Figure 1
Figure 1
Oral enanthema.
Figure 2
Figure 2
Erythematous purpuric macules and papules, and isolated blisters, located on the feet.
Figure 3
Figure 3
Multiple erythematous papules, with confluent areas, located on the hands.
Figure 4
Figure 4
Skin biopsy on the arm showing intraepidermal blister and intense spongiosis (Hematoxylin & eosin, 40×).
Figure 5
Figure 5
Serous blister formation with eosinophils and lymphocytes are observed. Edematous papillary dermis with mononuclear perivascular infiltration (Hematoxylin & eosin, 400×).
See this image and copyright information in PMC

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