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Comment
. 2022 Apr;43(4):274-276.
doi: 10.1016/j.it.2022.02.010. Epub 2022 Mar 8.

Tfh cells induce intratumoral tertiary lymphoid structures

Lisa Schmidleithner  1 , Markus Feuerer  2
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Comment

Tfh cells induce intratumoral tertiary lymphoid structures

Lisa Schmidleithner et al. Trends Immunol. 2022 Apr.

Abstract

Tertiary lymphoid structures (TLS) are highly organized ectopic structures found in nonlymphoid organs under chronic inflammatory conditions, including cancer. A recent study by Chaurio et al. reports that repression of Satb1 in CD4+ T cells can lead to increased Tfh cell differentiation, driving intratumoral TLS formation, resulting in reduced tumor growth in mice.

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Conflict of interest statement

Declaration of interests No interests are declared.

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