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Comment
. 2022 Apr;43(4):271-273.
doi: 10.1016/j.it.2022.02.009. Epub 2022 Feb 28.

SARS-CoV-2 vaccination washes away original antigenic sin

Shiv Pillai  1
Affiliations
Comment

SARS-CoV-2 vaccination washes away original antigenic sin

Shiv Pillai. Trends Immunol. 2022 Apr.

Abstract

According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also known as 'original antigenic sin', and this results in limited immunological breadth.

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Conflict of interest statement

No interests are declared.

Figures

Figure 1
Figure 1
Spike vaccination generates greater antibody breadth than natural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19). Vaccination leads to germinal center formation and greater antibody breadth while natural SARS-CoV-2 infection and COVID-19 itself results in germinal center disruption and the production of antibodies with diminished breadth, as assessed by their relative inability to bind viral variants [1]. Figure created with Biorender.com
See this image and copyright information in PMC

Comment on

  • Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination.
    Röltgen K, Nielsen SCA, Silva O, Younes SF, Zaslavsky M, Costales C, Yang F, Wirz OF, Solis D, Hoh RA, Wang A, Arunachalam PS, Colburg D, Zhao S, Haraguchi E, Lee AS, Shah MM, Manohar M, Chang I, Gao F, Mallajosyula V, Li C, Liu J, Shoura MJ, Sindher SB, Parsons E, Dashdorj NJ, Dashdorj ND, Monroe R, Serrano GE, Beach TG, Chinthrajah RS, Charville GW, Wilbur JL, Wohlstadter JN, Davis MM, Pulendran B, Troxell ML, Sigal GB, Natkunam Y, Pinsky BA, Nadeau KC, Boyd SD. Röltgen K, et al. Cell. 2022 Mar 17;185(6):1025-1040.e14. doi: 10.1016/j.cell.2022.01.018. Epub 2022 Jan 25. Cell. 2022. PMID: 35148837 Free PMC article.

References

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