Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2022 Mar 10;12(1):3960.
doi: 10.1038/s41598-022-06613-w.

Usefulness of presepsin for the early detection of infectious complications after elective colorectal surgery, compared with C-reactive protein and procalcitonin

Erika Amanai  1 , Kishiko Nakai  2 , Junichi Saito  3 , Eiji Hashiba  3 , Takuya Miura  4 , Hajime Morohashi  4 , Yoshiyuki Sakamoto  4 , Akio Mikami  5 , Kenichi Hakamada  4 , Kazuyoshi Hirota  6
Affiliations
Observational Study

Usefulness of presepsin for the early detection of infectious complications after elective colorectal surgery, compared with C-reactive protein and procalcitonin

Erika Amanai et al. Sci Rep. .

Abstract

Infectious complications remain a major clinical problem in colorectal surgery. Presepsin has been reported to be a useful marker to diagnose sepsis, similar or superior to procalcitonin (PCT) and C-reactive protein (CRP). The aim of this study was to assess the diagnostic value of presepsin in the early detection of infectious complications after elective colorectal surgery, compared with CRP and PCT. This study was a prospective observational study. Patients of age > 18 who underwent elective colon resections were enrolled. Blood samples were collected just before surgery and on postoperative day (POD) 1, 2, 3, 4, and 6 to measure plasma levels of biomarkers. We evaluated the association between circulating biomarkers and infections. A total of 114 patients were examined, and 27 patients (23.7%) developed infectious complications. CRP and PCT markedly increased from POD 1 to POD 3 and then gradually decreased toward POD 6 in both groups, but the trends of the decrease in the infected group were blunt, compared with those in the non-infected group. On the other hand, presepsin did not show major changes just after surgery, but it increased on POD 4 and POD 6, when the complications occurred. Monitoring the presepsin trends after colorectal surgeries could be helpful to detect postoperative infectious complications.Trial registration: UMIN000025313. Registered on 17 December 2016.

PubMed Disclaimer

Conflict of interest statement

LSI Medience Corporation provided the kits for measuring presepsin (PATHFAST; Mitsubishi Chemical Medience Corporation, Tokyo) free of cost.

Figures

Figure 1
Figure 1
Time course of plasma concentrations of presepsin, CRP and procalcitonin. Plasma concentrations of presepsin, CRP and procalcitonin before surgery and on postoperative day 1, 2, 3, 4, and 6. Data are shown as mean and SEM. Two-way analysis of variance (ANOVA) with repeated measures was done on log-transformed data. There were significant differences between groups for presepsin, CRP, and procalcitonin concentrations. *p < 0.05 between groups. †p < 0.05 versus preoperative.
See this image and copyright information in PMC

References

    1. Wick EC, et al. Surgical site infections and cost in obese patients undergoing colorectal surgery. Arch. Surg. 2011;146:1068–1072. doi: 10.1001/archsurg.2011.117. - DOI - PubMed
    1. de Lissovoy G, Fraeman K, Hutchins V, Murphy D, Song D, Vaughn BB. Surgical site infection: Incidence and impact on hospital utilization and treatment costs. Am. J. Infect. Control. 2009;37:387–397. doi: 10.1016/j.ajic.2008.12.010. - DOI - PubMed
    1. Wick EC, Vogel JD, Church JM, Remzi F, Fazio VW. Surgical site infections in a “high outlier” institution: Are colorectal surgeons to blame? Dis. Colon Rectum. 2009;52:374–379. doi: 10.1007/DCR.0b013e31819a5e45. - DOI - PubMed
    1. Bratzler DW, Hunt DR. The surgical infection prevention and surgical care improvement projects: National initiatives to improve outcomes for patients having surgery. Clin. Infect. Dis. 2006;43:322–330. doi: 10.1086/505220. - DOI - PubMed
    1. Keenan JE, Speicher PJ, Thacker JK, Walter M, Kuchibhatla M, Mantyh CR. The preventive surgical site infection bundle in colorectal surgery: An effective approach to surgical site infection reduction and health care cost savings. JAMA. 2014;149:1045–1052. - PubMed

Publication types

MeSH terms

Associated data