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. 2022 Feb 22:13:795479.
doi: 10.3389/fgene.2022.795479. eCollection 2022.

Circulating N-Terminal Probrain Natriuretic Peptide Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study

Ming Li  1 , Yi Xu  1   2 , Jiaqi Wu  3 , Chuanjie Wu  2 , Ang Li  4 , Xunming Ji  1   2   3
Affiliations

Circulating N-Terminal Probrain Natriuretic Peptide Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study

Ming Li et al. Front Genet. .

Abstract

Mendelian randomization was used to evaluate the potential causal association between N-terminal probrain natriuretic peptide (NT-proBNP) and ischemic stroke based on summary statistics data from large-scale genome-wide association studies. Three single-nucleotide polymorphisms (SNPs) rs198389, rs13107325, and rs11105306 associated with NT-proBNP levels found in large general populations and in patients with acute heart disease were used as instrumental variables. The results of genetic association analysis of each single SNP show that there is no significant association between NT-proBNP levels and ischemic stroke or its subtypes, whereas rs198389 alone has a suggestive association with large-artery atherosclerosis stroke. The MR analysis of three SNPs shows that NT-proBNP levels may reduce the risk of small-vessel occlusion stroke suggestively. This genetic analysis provides insights into the pathophysiology and treatment of ischemic stroke.

Keywords: N-terminal pro-brain natriuretic peptide; mendelian randomization; risk predictor; single nucleotide polymorphisms; stroke.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic diagram of the MR assumptions. The arrows represent possible causal associations between variables. The dashed lines represent possible causal associations between variables that would violate the MR assumptions.
FIGURE 2
FIGURE 2
The retrieval process and inclusion/discharge criteria of instrumental variables.
FIGURE 3
FIGURE 3
The forest plot of the MR analysis.
See this image and copyright information in PMC

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