Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 15;14(2):1332-1338.
eCollection 2022.

Treatment efficacy of Lianhua Qingwen capsules for eraly-stage COVID-19

Si-Jia Fan  1 , Jian-Kun Liao  1 , Liu Wei  2 , Bai-Yu Wang  3 , Liu Kai  1 , Du-Xun Tan  1
Affiliations

Treatment efficacy of Lianhua Qingwen capsules for eraly-stage COVID-19

Si-Jia Fan et al. Am J Transl Res. .

Abstract

Objective: To systematically determine the effect of Lianhua Qingwen Capsules on the early antiviral and anti-inflammatory action against COVID-19 (Coronavirus 2019) and its applicational value in the treatment of COVID-19.

Methods: The clinical data of 66 early-mid-stage COVID-19 patients admitted to hospitals in Guangzhou between January 2020 and April 2020 were retrospectively analyzed. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in the control group (n=33). The two groups were compared in terms of clinical effects and main symptom (fever, cough and fatigue) disappearance rate.

Results: In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group.

Conclusion: Lianhua Qingwen Capsules can significantly improve the total effective rate for COVID-19 patients, as well as shorten the hospital stay and treatment time, which is worth of promotion in the clinic.

Keywords: COVID-19; Lianhua Qingwen; clinical symptoms; retrospective study; total effective rate; traditional Chinese medicine (TCM) treatment.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Chest radiographs. A: Chest radiograph of normal people; B: Chest radiograph of a patient with early-mid-stage COVID-19.
Figure 2
Figure 2
Chest radiographs of the patient. A: Before treatment; B: After treatment.
Figure 3
Figure 3
CT images of patient Mr. Lin (Male, Fifty-five years old) during different treatment periods. A: CT at admission (February 14, 2020); B: CT Reexamination after treatment (February 25, 2020); C: CT Reexamination after treatment (March 13, 2020); D: CT Reexamination after discharge (June 11, 2020).
See this image and copyright information in PMC

References

    1. The Lancet Respiratory Medicine. COVID-19 transmission-up in the air. Lancet Respir Med. 2020;8:1159. - PMC - PubMed
    1. Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges. Int J Antimicrob Agents. 2020;55:105924. - PMC - PubMed
    1. Poletti P, Tirani M, Cereda D, Trentini F, Guzzetta G, Sabatino G, Marziano V, Castrofino A, Grosso F, Del Castillo G, Piccarreta R, Andreassi A, Melegaro A, Gramegna M, Ajelli M, Merler S ATS Lombardy COVID-19 Task Force. Association of age with likelihood of developing symptoms and critical disease among close contacts exposed to patients with confirmed sars-cov-2 infection in Italy. JAMA Netw Open. 2021;4:e211085. - PMC - PubMed
    1. Wu D, Wu T, Liu Q, Yang Z. The SARS-CoV-2 outbreak: what we know. Int J Infect Dis. 2020;94:44–48. - PMC - PubMed
    1. Peeri NC, Shrestha N, Rahman MS, Zaki R, Tan Z, Bibi S, Baghbanzadeh M, Aghamohammadi N, Zhang W, Haque U. The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? Int J Epidemiol. 2020;49:717–726. - PMC - PubMed

LinkOut - more resources