Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Feb 22:9:851147.
doi: 10.3389/fsurg.2022.851147. eCollection 2022.

Case Report: Benign Uterine Adenomyoma Metastasis in the Right Lung

Xiaowei Zhang  1 , Hongquan Jiang  2 , Bifei Huang  1 , Hangping Wei  3
Affiliations
Case Reports

Case Report: Benign Uterine Adenomyoma Metastasis in the Right Lung

Xiaowei Zhang et al. Front Surg. .

Abstract

Background: Pulmonary metastasis of benign uterine leiomyoma and uterine endometriosis has been reported; however, pulmonary benign metastasizing uterine adenomyoma has not been reported. Herein, we report the first case of pulmonary benign metastasizing uterine adenomyoma. It is very important to differentiate from pulmonary primary synovial sarcoma; histopathology and immunohistochemistry are very helpful, molecular pathology can be used if necessary.

Case presentation: A female patient was admitted to the hospital because of pulmonary nodules. Lung computed tomography (CT) showed a nodular high density shadow in the upper lobe of the right lung, with a clear boundary and a diameter of approximately 1.2 cm. A contrast CT scan showed obvious enhancement, and no obvious lobulation or burr was found. Video-assisted thoracoscopic resection of the tumor was performed. The upper lobe nodules were completely removed. Postoperative pathological report confirmed the lesion as metastatic benign adenomyoma of the right upper lung.

Conclusion: The lung is the most common organ for malignant tumor metastasis, and a few benign tumors can also develop pulmonary metastasis. Pulmonary benign metastasizing adenomyoma is extremely rare, and the prognosis is very good after surgical resection. When pulmonary CT shows a solid high-density shadow, we should consider the possibility of a metastatic benign tumor.

Keywords: adenomyoma; benign; metastasis; pulmonary; uterine.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
CT images of this case: (A) Lung CT showed a round high-density shadow in the upper lobe of the right lung, with clear boundary and smooth edge, without lobulation and burr; (B) Enhanced CT of the lung showed significant continuous enhancement.
Figure 2
Figure 2
Histologic findings: (A) Microscopically, the tumor was composed of proliferative spindled smooth muscle cells and endometrial glands (Hematoxylin and eosin stain, × 200); (B) The spindled smooth muscle cells were strongly positive for desmin (IHC, × 100); (C) Tumor cells were positive for ER (IHC, × 100); (D) The tumor cells were positive for PR (IHC, × 100).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Miller J, Shoni M, Siegert C, Lebenthal A, Godleski J, McNamee C. Benign metastasizing leiomyomas to the lungs: an institutional case series and a review of the recent literature. Ann Thorac Surg. (2016) 101:253–8. 10.1016/j.athoracsur.2015.05.107 - DOI - PubMed
    1. Stewart CJ, Leung YC, Mathew R, McCartney AL. Extrauterine adenomyoma with atypical (symplastic) smooth muscle cells: a report of 2 cases. Int J Gynecol Pathol. (2009) 28:23–8. 10.1097/PGP.0b013e3181815371 - DOI - PubMed
    1. Gruttadauria M, Wen X, Burke WM. Extrauterine adenomyomas presenting in a 47 year old woman with a previous cesarean section. Gynecol Oncol Rep. (2019) 31:100524. 10.1016/j.gore.2019.100524 - DOI - PMC - PubMed
    1. Paul PG, Gulati G, Shintre H, Mannur S, Paul G, Mehta S. Extrauterine adenomyoma: a review of the literature. Eur J Obstet Gynecol Reprod Biol. (2018) 228:130–6. 10.1016/j.ejogrb.2018.06.021 - DOI - PubMed
    1. Patton KT, Cheng L, Papavero V, Blum MG, Yeldandi AV, Adley BP, et al. . Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. Mod Pathol. (2006) 19:130–40. 10.1038/modpathol.3800504 - DOI - PubMed

Publication types

LinkOut - more resources