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. 2022 Jul;42(7):1593-1604.
doi: 10.1111/liv.15239. Epub 2022 Mar 29.

Disease burden and management of Crigler-Najjar syndrome: Report of a world registry

Sem J Aronson  1 , Norman Junge  2 , Mediha Trabelsi  3   4 , Wided Kelmemi  3 , Aurelie Hubert  5 , Karlla W Brigatti  6 , Michael D Fox  6   7 , Robert J de Knegt  8 , Johanna C Escher  9 , Virginia M Ginocchio  10 , Raffaele Iorio  10 , Yan Zhu  11 , Figen Özçay  12 , Fakher Rahim  13   14 , Mortada H F El-Shabrawi  15 , Eyal Shteyer  16 , Angelo Di Giorgio  17 , Lorenzo D'Antiga  17 , Federico Mingozzi  18 , Nicola Brunetti-Pierri  10   19 , Kevin A Strauss  6   20 , Philippe Labrune  5 , Ridha Mrad  3   4 , Ulrich Baumann  2 , Ulrich Beuers  1 , Piter J Bosma  1 ; CureCN Consortium
Affiliations

Disease burden and management of Crigler-Najjar syndrome: Report of a world registry

Sem J Aronson et al. Liver Int. 2022 Jul.
No abstract available

Keywords: UGT1A1; encephalopathy; liver transplantation; phototherapy; unconjugated hyperbilirubinemia.

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References

REFERENCES

    1. Crigler JF Jr, Najjar VA. Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics. 1952;10:169-180.
    1. Bosma PJ, Seppen J, Goldhoorn B, et al. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem. 1994;269:17960-17964.
    1. Bortolussi GMA. Advances in understanding disease mechanisms and potential treatments for Crigler-Najjar syndrome. Expert Opin Orphan Drugs. 2018;6:425-439.
    1. Cremer RJ, Perryman PW, Richards DH. Influence of light on the hyperbilirubinaemia of infants. Lancet. 1958;1:1094-1097.
    1. van der Veere CN, Sinaasappel M, McDonagh AF, et al. Current therapy for Crigler-Najjar syndrome type 1: report of a world registry. Hepatology. 1996;24:311-315.

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