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Review
. 2022 Apr 12;17(4):734-740.
doi: 10.1016/j.stemcr.2022.02.003. Epub 2022 Mar 10.

Aging of intestinal stem cells

Kodandaramireddy Nalapareddy  1 , Yi Zheng  1 , Hartmut Geiger  2
Affiliations
Review

Aging of intestinal stem cells

Kodandaramireddy Nalapareddy et al. Stem Cell Reports. .

Abstract

The intestine is one of the organs that relies on stem cell function for maintaining tissue homeostasis. Recent findings on intestinal aging show that intestinal architecture, such as villus length, crypt size, and cell composition changes in the aged crypts. The correspondent decline in the regenerative capacity of the intestine is mainly due to a decline in intestinal stem cell function upon aging, as the underlying mechanisms of aging intestinal stem cells are beginning to unravel. This review summarizes our current knowledge on stem cell-intrinsic mechanisms of aging of intestinal stem cells and their connection to extrinsic factors, such as niche cells and microbiota and will introduce recent approaches to attenuate or even revert the aging of intestinal stem cells.

Keywords: Cdc42 activity; Wnt; aging; intestinal stem cells.

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Conflict of interest statement

Conflicts of interest The authors declare no competing interests.

Figures

None
Graphical abstract
Figure 1
Figure 1
Schematics of crypt and villus in intestinal epithelium, where ISCs reside at the crypt base flanked by Paneth cells (niche cells) ISCs differentiate to transient amplifying cells that reach to the end of crypt and further differentiate to villus (i.e., the absorptive surface) that comprises enterocytes, goblet cells, and enteroendocrine cells.
See this image and copyright information in PMC

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