Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 24;14(3):499.
doi: 10.3390/nu14030499.

Dietary Habits of a Group of Children with Crohn's Disease Compared to Healthy Subjects: Assessment of Risk of Nutritional Deficiencies through a Bromatological Analysis

Flavio Labriola  1 , Caterina Marcato  1 , Chiara Zarbo  1 , Ludovica Betti  2 , Arianna Catelli  2 , Maria Chiara Valerii  3 , Enzo Spisni  3 , Patrizia Alvisi  1
Affiliations

Dietary Habits of a Group of Children with Crohn's Disease Compared to Healthy Subjects: Assessment of Risk of Nutritional Deficiencies through a Bromatological Analysis

Flavio Labriola et al. Nutrients. .

Abstract

Diet is a matter of interest in the pathogenesis and management of Crohn's Disease (CD). Little is known about CD children's dietary habits. Our aim was assessing the quality and the amount of nutrient intake in a group of CD pediatric patients. Data were compared with those of healthy subjects (HS). In total, 20 patients (13 males) and 48 HS (24 males) aged 4-18 years were provided with a food diary to fill out for one week. Winfood software performed the bromatological analysis, providing data about intakes of proteins and amino acids, fatty acids, carbohydrates, cholesterol, fibers, minerals, vitamins, and polyphenols. Estimates of the antioxidant activity of foods and of the dietetic protein load were also calculated. The diet of CD patients was poorer in fibers, polyphenols, vitamin A, beta-carotene, and fatty acids, and richer in animal proteins, vitamin B12, and niacin. PRAL was higher in CD patients' diets, while ORAC was higher in HS. No significant differences were observed in carbohydrate and other macro- and micronutrient consumptions. CD dietary habits seem to reflect the so-called Western diet, possibly involved in CD pathogenesis. Furthermore, analysis of dietary habits allows for prevention of nutritional deficiencies and timely correction through education and supplementation.

Keywords: Crohn’s disease; bromatology; dietary intake; micronutrients; nutritional deficiencies.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Graphic representation of tbe most relevant statistically significant results. (A) Total fibers; (B) Animal proteins; (C) Vitamin A; (D) Polyphenols; (E) PRAL; (F) ORAC. Boxes represent IQR and horizontal middle lines are medians. Whiskers highlight minimum and maximum values. p-values are mentioned in the text. HS: Healthy subjects. CD: Crohn’s disease. ORAC: Oxygen Radical Absorbance Capacity. PRAL: Potential Renal Acid Load.
Figure 1
Figure 1
Graphic representation of tbe most relevant statistically significant results. (A) Total fibers; (B) Animal proteins; (C) Vitamin A; (D) Polyphenols; (E) PRAL; (F) ORAC. Boxes represent IQR and horizontal middle lines are medians. Whiskers highlight minimum and maximum values. p-values are mentioned in the text. HS: Healthy subjects. CD: Crohn’s disease. ORAC: Oxygen Radical Absorbance Capacity. PRAL: Potential Renal Acid Load.
See this image and copyright information in PMC

References

    1. Mills S.C., von Roon A.C., Tekkis P.P., Orchard T.R. Crohn’s Disease. BMJ Clin. Evid. 2011;2011:0416. - PMC - PubMed
    1. Griffiths A.M. Specificities of Inflammatory Bowel Disease in Childhood. Best Pract. Res. Clin. Gastroenterol. 2004;18:509–523. doi: 10.1016/j.bpg.2004.01.002. - DOI - PubMed
    1. Kaplan G.G. The Global Burden of IBD: From 2015 to 2025. Nat. Rev. Gastroenterol. Hepatol. 2015;12:720–727. doi: 10.1038/nrgastro.2015.150. - DOI - PubMed
    1. Molodecky N.A., Soon I.S., Rabi D.M., Ghali W.A., Ferris M., Chernoff G., Benchimol E.I., Panaccione R., Ghosh S., Barkema H.W., et al. Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases with Time, Based on Systematic Review. Gastroenterology. 2012;142:46–54. doi: 10.1053/j.gastro.2011.10.001. - DOI - PubMed
    1. Sýkora J., Pomahačová R., Kreslová M., Cvalínová D., Štych P., Schwarz J. Current Global Trends in the Incidence of Pediatric-Onset Inflammatory Bowel Disease. World J. Gastroenterol. 2018;24:2741–2763. doi: 10.3748/wjg.v24.i25.2741. - DOI - PMC - PubMed