Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Feb 5;14(3):679.
doi: 10.3390/nu14030679.

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Nicola Veronese  1 , Damiano Pizzol  2 , Lee Smith  3 , Ligia J Dominguez  1   4 , Mario Barbagallo  1
Affiliations
Meta-Analysis

Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Nicola Veronese et al. Nutrients. .

Abstract

Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23 November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present. In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1. In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.

Keywords: C reactive protein; inflammation; magnesium; meta-analysis; randomized controlled trial; tumor necrosis factor.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow-chart.
Figure 2
Figure 2
Forrest plot of the effect of magnesium versus placebo on serum C-reactive protein [17,24,25,26,27,28,29,30,31,32,33,35,36,38,39].
Figure 3
Figure 3
Forrest plot of the effect of magnesium versus placebo on serum nitric oxide [17,32,33].
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Veronese N., Demurtas J., Pesolillo G., Celotto S., Barnini T., Calusi G., Caruso M.G., Notarnicola M., Reddavide R., Stubbs B. Magnesium and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational and intervention studies. Eur. J. Nutr. 2020;59:263–272. doi: 10.1007/s00394-019-01905-w. - DOI - PubMed
    1. Caspi R., Altman T., Billington R., Dreher K., Foerster H., Fulcher C.A., Holland T.A., Keseler I.M., Kothari A., Kubo A. The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases. Nucleic Acids Res. 2014;42:D459–D471. doi: 10.1093/nar/gkt1103. - DOI - PMC - PubMed
    1. Kovacs L., Molnar B., Huhn E., Bodis L. Magnesium substitution in pregnancy. A prospective, randomized double-blind study. Geburtshilfe Frauenheilkd. 1988;48:595–600. - PubMed
    1. Bartal M.F., Sibai B.M. Eclampsia in the 21st century. Am. J. Obstet. Gynecol. 2020 doi: 10.1016/j.ajog.2020.09.037. ahead of print . - DOI - PubMed
    1. Fanni D., Gerosa C., Nurchi V., Manchia M., Saba L., Coghe F., Crisponi G., Gibo Y., Van Eyken P., Fanos V. The role of magnesium in pregnancy and in fetal programming of adult diseases. Biol. Trace Elem. Res. 2021;199:3647–3657. doi: 10.1007/s12011-020-02513-0. - DOI - PMC - PubMed

Publication types