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. 2022 Nov-Dec;88 Suppl 4(Suppl 4):S89-S97.
doi: 10.1016/j.bjorl.2021.11.003. Epub 2021 Dec 4.

Nutritional and immunological parameters as prognostic factors in patients with advanced oral cancer

Lorenzo Fernandes Moça Trevisani  1 , Isabelle Fernandes Kulcsar  2 , Ana Kober Nogueira Leite  3 , Marco Aurélio Vamondes Kulcsar  3 , Graziele Aparecida Simões Lima  4 , Rogerio Aparecido Dedivitis  5 , Luiz Paulo Kowalski  5 , Leandro Luongo Matos  6
Affiliations

Nutritional and immunological parameters as prognostic factors in patients with advanced oral cancer

Lorenzo Fernandes Moça Trevisani et al. Braz J Otorhinolaryngol. 2022 Nov-Dec.

Abstract

Objective: The aim of the present study was to analyze the prognostic relationship of weight loss and preoperative hematological indexes in patients surgically treated for pT4a squamous cell carcinoma of the oral cavity.

Methods: A retrospective cohort study.

Results: Percent weight loss greater than 10% was identified in 49 patients (28.2%), and any weight loss in relation to the usual weight occurred in 140 patients (78.7%). Percent weight loss greater than 10% (HR = 1.679), Red cell distribution width (RDW) values greater than 14.3% (HR = 2.210) and extracapsular spread (HR = 1.677) were independent variables associated with risk of death.

Conclusion: Patients with advanced squamous cell carcinoma of the oral cavity present significant weight loss and as significantly immunocompromised. Increased values of RDW and higher percentages of weight loss in relation to the individual's usual weight, together with extracapsular spread of metastatic lymph nodes, were risk factors for lower survival, regardless of other clinical and anatomopathological characteristics.

Keywords: Body weight changes; Carcinoma, squamous cell; Nutrition; Oral cavity; Prognosis.

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Figures

Figure 1
Figure 1
Kaplan-Meier curves showing the overall survival of patients with advanced squamous cell carcinoma (pT4a) of the oral cavity in relation to the independent risk variables. (A) Lower overall survival in patients with extracapsular spread (6.6% vs. 38.5%; p = 0.004 – log-rank test); (B) lower overall survival in patients with RDW < 14.3% (27.5% vs. 31.1%; p < 0.001 – log-rank test); (C) lower overall survival in patients with weight loss greater than 10% in relation to their usual weight (8.9% vs. 37%; p < 0.001 – log-rank test).
See this image and copyright information in PMC

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