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. 2022 Jun;19(6):653-654.
doi: 10.1038/s41423-022-00846-5. Epub 2022 Mar 11.

Trained through generations

Affiliations

Trained through generations

Neha D Patil et al. Cell Mol Immunol. 2022 Jun.
No abstract available

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Conflict of interest statement

MSD works as a consultant and an advisory board member at Theralution GmbH, Germany. The other authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Schematic representation of the inter- and transgenerational transmission of trained immunity.

References

    1. Katzmarski N, Dominguez-Andrés J, Cirovic B, Renieris G, Ciarlo E, Le Roy D, et al. Transmission of trained immunity and heterologous resistance to infections across generations. Nat Immunol. 2021;22:1382–90. doi: 10.1038/s41590-021-01052-7. - DOI - PubMed
    1. Netea MG, Quintin J, van der Meer JWM. Trained immunity: a memory for innate host defense. Cell Host Microbe. 2011;9:355–61. doi: 10.1016/j.chom.2011.04.006. - DOI - PubMed
    1. Netea MG, Latz E, Mills KHG, O’Neill LAJ. Innate immune memory: a paradigm shift in understanding host defense. Nat Immunol. 2015;16:675–9. doi: 10.1038/ni.3178. - DOI - PubMed
    1. Soto JA, Gálvez NMS, Andrade CA, Ramírez MA, Riedel CA, Kalergis AM, et al. BCG vaccination induces cross-protective immunity against pathogenic microorganisms. Trends Immunol. 10.1016/j.it.2021.12.006. - PubMed
    1. de Candia P, Matarese G. Reimagining an immunological dogma. Nat Immunol. 2021;22:1355–8. doi: 10.1038/s41590-021-01046-5. - DOI - PubMed