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. 2022 Oct;36(10):7431-7443.
doi: 10.1007/s00464-022-09156-3. Epub 2022 Mar 11.

Single-operator peroral pancreatoscopy in the preoperative diagnostics of suspected main duct intraductal papillary mucinous neoplasms: efficacy and novel insights on complications

Sini Vehviläinen  1   2 , Niklas Fagerström  3 , Roberto Valente  4   5 , Hanna Seppänen  1   2 , Marianne Udd  1   2 , Outi Lindström  1   2 , Harri Mustonen  1   2 , Fredrik Swahn  6 , Urban Arnelo  7   8 , Leena Kylänpää  1   2
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Single-operator peroral pancreatoscopy in the preoperative diagnostics of suspected main duct intraductal papillary mucinous neoplasms: efficacy and novel insights on complications

Sini Vehviläinen et al. Surg Endosc. 2022 Oct.

Abstract

Background: Distinguishing intraductal papillary mucinous neoplasms (IPMNs) from other pancreatic cystic lesions is essential since IPMNs carry the risk of becoming malignant. Differentiating the main pancreatic duct involving IPMNs (MD-IPMNs) through conventional imaging is deficient. Single-operator peroral pancreatoscopy (SOPP) represents a promising method offering additional information on suspected lesions in the pancreatic main duct (MD). We aimed to determine the role of SOPP in the preoperative diagnostics of suspected MD-IPMNs and identify factors contributing to SOPP-related complications.

Materials and methods: In this primarily retrospective study, SOPPs were performed at three high-volume centers on suspected MD-IPMNs. Primary outcome was the clinical impact of SOPP to subsequent patient care. Additionally, we documented post-SOPP complications and analyzed several assumed patient- and procedure-related risk factors.

Results: One hundred and one (101) SOPPs were performed. Subsequent clinical management was affected due to the findings in 86 (85%) cases. Surgery was planned for 29 (29%) patients. A condition other than IPMN explaining MD dilatation was found in 28 (28%) cases. In 35 (35%) cases, follow-up with MRI was continued. Post-SOPP pancreatitis occurred in 20 (20%) patients and one of them was fatal. A decrease in odds of post-SOPP pancreatitis was seen as the MD diameter increases (OR 0.714 for 1.0 mm increase in MD diameter, CI 95% 0.514-0.993, p = 0.045). Furthermore, a correlation between lower MD diameter values and higher severity post-SOPP pancreatitis was seen (TJT = 599, SE = 116.6, z = - 2.31; p = 0.020). History of pancreatitis after endoscopic retrograde cholangiopancreatography was a confirmed risk factor for post-SOPP pancreatitis. Conclusions between complications and other risk factors could not be drawn.

Conclusion: SOPP aids clinical decision-making in suspected MD-IPMNs. Risk for post-SOPP pancreatitis is not negligible compared to non-invasive imaging methods. The risk for pancreatitis decreases as the diameter of the MD increases.

Keywords: IPMN; Pancreatitis; Post-ERCP pancreatitis; Single-operator pancreatoscopy.

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Conflict of interest statement

Roberto Valente received a grant from Boston Scientific for lecturing at the Finnish Pancreatic Club 2021. Urban Arnelo is consultant to Ambu and Boston Scientific and has received grants for investigator initiated and industry-sponsored studies from Boston Scientific. Sini Vehviläinen, Niklas Fagerström, Hanna Seppänen, Marianne Udd, Outi Lindström, Harri Mustonen, Fredrik Swahn, and Leena Kylänpää declare no conflict of interest or financial ties to disclose.

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