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Review
. 2022 Jul;49(7):6725-6739.
doi: 10.1007/s11033-022-07282-8. Epub 2022 Mar 11.

A review on the genetic polymorphisms and susceptibility of cancer patients in Bangladesh

Golap Babu  1 , Shad Bin Islam  2 , Md Asaduzzaman Khan  3
Affiliations
Review

A review on the genetic polymorphisms and susceptibility of cancer patients in Bangladesh

Golap Babu et al. Mol Biol Rep. 2022 Jul.

Abstract

Cancer is one of the major health burdens worldwide, and genetic polymorphisms in individuals are closely associated with cancer susceptibility. Like in many other developing countries, the risk of cancer is increasing among Bangladeshi population. Genetic polymorphisms in xenobiotic metabolic enzymes (CYP1A1, CYP2A6, CYP3A4, CYP3A5, NAT2, SULT1A), cell cycle regulatory proteins (TP53, HER2, MDM2, miR-218-2, TGFB), cell signaling protein (CDH1), DNA repair proteins (BRCA1, BRCA2, EXO1, RAD51, XRCC2, ECCR1, ERCC4, XPC, ERCC2), and others (HLA-DRB1, INSIG2, GCNT1P5) have been found to be associated with various cancers like cancers of breast, bladder, cervix, colon, lung, prostate, etc. in different studies with Bangladeshi population. In this review article, we have discussed these gene polymorphisms associated with cancers in the Bangladeshi population, and also made a comparison with other ethnic groups. This will probably be helpful in understanding drug effects, drug resistance, and personalized medicine in the population of this region.

Keywords: Bangladeshi population; Cancer susceptibility; Drug resistance; Genetic polymorphisms; Oncogenes; Tumor suppressors.

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