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. 2022 Mar;62(3):383-388.
doi: 10.1111/head.14282. Epub 2022 Mar 12.

Etoricoxib and celecoxib sensitive indomethacin-responsive headache disorders

Mena Farag  1 , Anish Bahra  1   2
Affiliations

Etoricoxib and celecoxib sensitive indomethacin-responsive headache disorders

Mena Farag et al. Headache. 2022 Mar.

Abstract

Indomethacin-responsive headaches encompass a group of disorders which include a subset of the trigeminal autonomic cephalalgias and other paroxysmal, often precipitated primary headaches. Many patients show a rapid therapeutic response to indomethacin, which is limited by intolerability. Etoricoxib and celecoxib, selective inhibitors of cyclo-oxygenase-2 (COX-2), spare gastroduodenal COX-1 activity and are less likely to cause gastrointestinal adverse effects than indomethacin. We report a case series of eight patients, seven who responded to etoricoxib and one patient who responded to celecoxib.

Keywords: celecoxib; cyclo-oxygenase-2 inhibitors; etoricoxib; indomethacin-responsive headache disorders.

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