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. 2022 Mar;29(3):1585-1591.
doi: 10.1016/j.sjbs.2021.11.005. Epub 2021 Nov 11.

Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats

Saad Alkahtani  1 , Md Saquib Hasnain  2 , Hamzah Algamdy  1 , Nada H Aljarba  3 , Abdullah AlKahtane  1
Affiliations

Acute and sub-acute oral toxicity Lagerstroemia speciosa in Sprague-Dawley rats

Saad Alkahtani et al. Saudi J Biol Sci. 2022 Mar.

Abstract

Through the boost of the natural medicinal market, individuals began to use a variety of organic materials in the marketed herbal preparation. Lagerstroemia speciosa (LS) leaves are known as banaba. People have been using a decoction of LS leaves as antidiabetic. The study aimed to investigate the acute and sub-acute oral toxicity of LS in Sprague-Dawley rats. The acute toxicity was determined by a single oral dose of LS (2000 mg/kg). Therein animal behaviour and mortality rate were observed for 14 days. The LS (200 mg/kg) was given for 28 days daily in the sub-acute study. The body weight, organ weight, food, water intake, biochemical, haematological parameters, and histopathology were studied. The findings of this study showed no mortality or morbidity was found in acute and sub-acute toxicity studies in rats. Additionally, no significant variations were found in the respective weight of organ, haematological and biochemical parameters of treated groups with reference to the control group. Moreover, no visible histological changes were detected in the liver of treated groups with reference to the control. In conclusion, the oral administration of LS did not fabricate any major toxic effect in rats. No toxic consequences were reported during acute and sub-acute toxicity investigations. Overall, LS is a safe, natural bio-actives as studied. Further investigations of cytotoxicity and genotoxicity of the above drug(s) or their combinations may be executed for appreciative safety.

Keywords: ALP, Alkaline phosphatase; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; Biochemical investigations; FBG, Fasting blood glucose; GSH, Reduced glutathione; Haematology; Histopathology; LS, Lagerstroemia speciosa; MDA, Malondialdehyde; ROS, Reactive oxygen species; SOD, Superoxide dismutase; Toxicity.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Effect of LS on (A) body weight, (B) fasting blood glucose level. Data are represented as mean ± SEM.
Fig. 2
Fig. 2
Effect of LS on different organ weights of the body of rat. Data are represented as mean ± SEM.
Fig. 3
Fig. 3
Effect of LS on (A) ROS, (B) MDA level, (C) GSH level, and (D) SOD activity. Data are represented as mean ± SEM.
Fig. 4
Fig. 4
Histopathological analysis of liver tissue on administration of LS in sub-acute toxicity.
See this image and copyright information in PMC

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