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Case Reports
. 2022 Mar 4:2022:9000608.
doi: 10.1155/2022/9000608. eCollection 2022.

A Case of Anti-SAE1 Dermatomyositis

Max de Vries  1 , Marco W J Schreurs  2 , Els J M Ahsmann  3 , Marcela Spee-Dropkova  4 , Faiz Karim  1
Affiliations
Case Reports

A Case of Anti-SAE1 Dermatomyositis

Max de Vries et al. Case Reports Immunol. .

Abstract

Introduction: Anti-SAE1 antibodies have a low prevalence in dermatomyositis patients. Case Description. A 61-year-old woman presented with progressive shortness of breath, arthralgia, heliotrope rash, Gottron's papules, and erythematous rash. She had an interstitial lung disease (ILD) with a significant decrease in lung function. There was no muscle involvement. Immunological laboratory test results showed strongly positive anti-SAE1 antibodies. Glucocorticoid treatment resulted in remission of dermatomyositis.

Conclusion: Anti-SAE antibodies in dermatomyositis patients are closely linked to unique clinical features.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Imaging studies of the patient. (a) CT-thorax 2018 (pretreatment): bilateral patchy consolidations with distortion and dilatation of the bronchioles and parenchymal distortion with peripheral subpleural and peribronchovascular distribution, which are compatible with an organizing pneumonia. (b) CT-thorax 2019 (posttreatment): bilateral atelectasis with traction bronchiectasis, which are compatible with residual abnormalities after an organizing pneumonia.
Figure 2
Figure 2
Skin biopsy and ANA determination. (a) H&E staining showing vacuolar changes in the basal layer of the epidermis (arrow) and perivascular lymphocytic infiltration of the dermis. (b) The IIF HEp-2 pattern showing a positive ANA with combined nuclear dense (AC-2) and fine speckled (AC-4) pattern (http://www.ANApatterns.org), the latter being compatible with anti-SAE1 reactivity. Arrows indicate fine speckled nucleoplasm in mitotic cells outside chromatin mass.
See this image and copyright information in PMC

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