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Review
. 2022 Feb 24:13:852272.
doi: 10.3389/fimmu.2022.852272. eCollection 2022.

Role of Histone Post-Translational Modifications in Inflammatory Diseases

Yingying Lin  1   2 , Ting Qiu  1   2 , Guifeng Wei  1   2 , Yueyue Que  1   2 , Wenxin Wang  1   3 , Yichao Kong  1   2 , Tian Xie  1   2 , Xiabin Chen  1   2
Affiliations
Review

Role of Histone Post-Translational Modifications in Inflammatory Diseases

Yingying Lin et al. Front Immunol. .

Abstract

Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer's disease, psoriasis, asthma, chronic lung diseases, inflammatory bowel disease, and multiple virus-associated diseases. Epigenetic mechanisms have been demonstrated to play a key role in the regulation of inflammation. Common epigenetic regulations are DNA methylation, histone modifications, and non-coding RNA expression; among these, histone modifications embrace various post-modifications including acetylation, methylation, phosphorylation, ubiquitination, and ADP ribosylation. This review focuses on the significant role of histone modifications in the progression of inflammatory diseases, providing the potential target for clinical therapy of inflammation-associated diseases.

Keywords: epigenetic; histone modifications; immune; inflammation; inflammatory diseases.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Overview of the role of histone modification in inflammatory disease.
Figure 2
Figure 2
Major epigenetic mechanisms in regulation of gene expression.
Figure 3
Figure 3
Histone acetylation mediated by the activities of HATs and HDACs.
See this image and copyright information in PMC

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