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Review
. 2022 Feb 23:13:817062.
doi: 10.3389/fimmu.2022.817062. eCollection 2022.

Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring

Lefei Jiao  1   2 , Chien-Wen Su  2 , Tinglan Cao  3 , Shasha Zheng  4 , W Allan Walker  2 , Hai Ning Shi  2
Affiliations
Review

Maternal Influences and Intervention Strategies on the Development of Food Allergy in Offspring

Lefei Jiao et al. Front Immunol. .

Abstract

Food allergies and other immune-mediated diseases have become serious health concerns amongst infants and children in developed and developing countries. The absence of available cures limits disease management to allergen avoidance and symptomatic treatments. Research has suggested that the presence of maternal food allergies may expose the offspring to genetic predisposition, making them more susceptible to allergen sensitization. The following review has focused on epidemiologic studies regarding maternal influences of proneness to develop food allergy in offspring. The search strategy was "food allergy OR maternal effects OR offspring OR prevention". A systematically search from PubMed/MEDLINE, Science Direct and Google Scholar was conducted. Specifically, it discussed the effects of maternal immunity, microbiota, breastfeeding, genotype and allergy exposure on the development of food allergy in offspring. In addition, several commonly utilized prenatal and postpartum strategies to reduce food allergy proneness were presented, including early diagnosis of high-risk infants and various dietary interventions.

Keywords: food allergy; high-risk infants; intervention strategies; maternal effect; maternal immunity; maternal microbiota.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The impact of maternal food allergy on offspring and the method of prevention and management.
See this image and copyright information in PMC

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