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Review
. 2022 Mar 4:2022:9349897.
doi: 10.1155/2022/9349897. eCollection 2022.

Biosynthesis of Secondary Metabolites Based on the Regulation of MicroRNAs

Rajib Hossain  1 , Cristina Quispe  2 , Abu Saim Mohammad Saikat  3 , Divya Jain  4 , Arslan Habib  5 , Pracheta Janmeda  4 , Muhammad Torequl Islam  1 , Radha  6 , Sevgi Durna Daştan  7   8 , Manoj Kumar  9 , Monica Butnariu  10 , William C Cho  11 , Javad Sharifi-Rad  12 , Aliya Kipchakbayeva  13 , Daniela Calina  14
Affiliations
Review

Biosynthesis of Secondary Metabolites Based on the Regulation of MicroRNAs

Rajib Hossain et al. Biomed Res Int. .

Abstract

MicroRNA (miRNA), a noncoding ribonucleic acid, is considered to be important for the progression of gene expression in plants and animals by rupture or translational repression of targeted mRNAs. Many types of miRNA regulate plant metabolism, growth, and response to biotic and abiotic factors. miRNA characterization helps to expose its function in regulating the process of post-transcriptional genetic regulation. There are a lot of factors associated with miRNA function, but the function of miRNA in the organic synthesis of by-products by natural products is not yet fully elucidated. The current review is aimed at observing and characterizing miRNAs and identifying those involved in the functioning of the biosynthesis of secondary metabolites in plants, with their use in controlled manipulation.

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Conflict of interest statement

The authors declared no conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of action of miRNAs in plants. miRNA: microRNA; pri-miRNA: primary transcripts; DCL1: RNAase dicer-like 1.
Figure 2
Figure 2
miRNA increases the activity of biosynthetic enzymes involved in flavonoid and isoflavonoid production and resulting in an improved yield of flavonoid and isoflavonoids.
Figure 3
Figure 3
miRNA improves the production of terpenoid compounds.
Figure 4
Figure 4
Role of miRNA in the synthesis of alkaloid and other N-containing metabolites.
See this image and copyright information in PMC

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