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Review
. 2022 Mar 4:16:647-659.
doi: 10.2147/OPTH.S349582. eCollection 2022.

Current Perspectives on Corneal Transplantation (Part 2)

Yee Ling Wong  1 , Siyin Liu  1   2 , Andrew Walkden  1   2
Affiliations
Review

Current Perspectives on Corneal Transplantation (Part 2)

Yee Ling Wong et al. Clin Ophthalmol. .

Abstract

Disease of the cornea is the third leading cause of blindness worldwide. Corneal graft surgery is one of the most successful forms of solid organ transplantations in humans, with ever increasing developments in surgical technique. To date, approximately 4504 corneal transplants are performed in the UK each year. While full thickness transplantation was the most commonly performed keratoplasty over the last few decades, selective lamellar transplantation of the diseased layers of the cornea has been universally adopted. This comprehensive review aims to provide an updated synthesis on different types of corneal transplantations, their treatment outcomes, and the associated complications of each procedure both in adult and pediatric populations. In addition, we also present an up-to-date summary of the emerging therapeutic approaches that have the potential to reduce the demand for donor-dependent keratoplasty.

Keywords: corneal blindness; corneal transplantation; graft rejection; graft survival; keratoplasty.

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Conflict of interest statement

SL is supported by the National Institute of Health Research (ACF-2019-06-009). The authors report no other conflicts of interest in this work.

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