Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Mar 4:16:631-646.
doi: 10.2147/OPTH.S289359. eCollection 2022.

Current Perspectives on Corneal Transplantation

Siyin Liu  1   2 , Yee Ling Wong  1 , Andrew Walkden  1   2
Affiliations
Review

Current Perspectives on Corneal Transplantation

Siyin Liu et al. Clin Ophthalmol. .

Abstract

Disease of the cornea is the third leading cause of blindness worldwide. Corneal graft surgery is one of the most successful forms of solid organ transplantations in humans, with ever-increasing developments in surgical technique. To date, approximately 4504 corneal transplants are performed in the United Kingdom each year. While full thickness transplantation was the most commonly performed keratoplasty over the last few decades, selective lamellar transplantation of the diseased layers of the cornea has been universally adopted. This comprehensive review aims to provide an updated synthesis on different types of corneal transplantations, their treatment outcomes, and the associated complications of each procedure in both adult and paediatric population. In addition, we also present an up-to-date summary of the emerging therapeutic approaches that have the potential to reduce the demand for donor-dependent keratoplasty.

Keywords: corneal blindness; corneal transplantation; graft rejection; graft survival; keratoplasty.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

References

    1. Gain P, Jullienne R, He Z, et al. Global survey of corneal transplantation and eye banking. JAMA Ophthalmol. 2016;134(2):167. doi:10.1001/jamaophthalmol.2015.4776 - DOI - PubMed
    1. Mathews PM, Lindsley K, Aldave AJ, Akpek EK. Etiology of global corneal blindness and current practices of corneal transplantation: a focused review. Cornea. 2018;37:6. - PubMed
    1. Streilein JW, Yamada J, Dana MR, Ksander BR. Anterior chamber-associated immune deviation, ocular immune privilege, and orthotopic corneal allografts. Transplant Proc. 1999;31(3):1472–1475. doi:10.1016/S0041-1345(99)00010-X - DOI - PubMed
    1. Wang HM, Kaplan HJ, Chan WC, Johnson M. The distribution and ontogeny of MHC antigens in murine ocular tissue. Invest Ophthalmol Vis Sci. 1987;28(8):1383–1389. - PubMed
    1. Annual activity report - cornea activity. ODT clinical - NHS blood and transplant: annual activity report - cornea activity. Available from: https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/19197/section.... Accessed June 7, 2021.