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Multicenter Study
. 2022 Nov 25;159(10):457-464.
doi: 10.1016/j.medcli.2022.01.008. Epub 2022 Mar 10.

Mortality risk factors in patients with SARS-CoV-2 infection and atrial fibrillation: Data from the SEMI-COVID-19 registry

[Article in English, Spanish]
Javier Azaña Gómez  1 , Luis M Pérez-Belmonte  2 , Manuel Rubio-Rivas  3 , José Bascuñana  4 , Raúl Quirós-López  5 , María Luisa Taboada Martínez  6 , Esther Montero Hernandez  7 , Fernando Roque-Rojas  8 , Manuel Méndez-Bailón  9 , Ricardo Gómez-Huelgas  2 ; en nombre del grupo SEMI-COVID-19
Affiliations
Multicenter Study

Mortality risk factors in patients with SARS-CoV-2 infection and atrial fibrillation: Data from the SEMI-COVID-19 registry

[Article in English, Spanish]
Javier Azaña Gómez et al. Med Clin (Barc). .

Abstract

Introduction: Atrial fibrillation and associated comorbidities pose a risk factor for mortality, morbidity and development of complications in patients admitted for COVID-19.

Objectives: To describe the clinical, epidemiological, radiological and analytical characteristics of patients with atrial fibrillation admitted for COVID-19 in Spain. Secondarily, we aim to identify those variables associated with mortality and poor prognosis of COVID-19 in patients with atrial fibrillation.

Methods: Retrospective, observational, multicenter, nationwide, retrospective study of patients hospitalized for COVID-19 from March 1 to October 1, 2020. Data were obtained from the SEMI-COVID-19 Registry of the Spanish Society of Internal Medicine (SEMI) in which 150 Spanish hospitals participate.

Results: Between March 1 and October 1, 2020, data from a total of 16,461 patients were entered into the SEMI-COVID-19 registry. 1816 (11%) had a history of atrial fibrillation and the number of deaths among AF patients amounted to 738 (41%). Regarding clinical characteristics, deceased patients were admitted with a higher heart rate (88.38 vs. 84.95; P>0.01), with a higher percentage of respiratory failure (67.2 vs. 20.1%; P<0.01) and high tachypnea (58 vs. 30%; P<0.01). The comorbidities that presented statistically significant differences in the deceased group were: age, hypertension and diabetes with target organ involvement. There was also a higher prevalence of a history of cardiovascular disease in the deceased. On multivariate analysis, DOACs treatment had a protective role for mortality (OR: 0.597; CI: 0.402-0.888; P=0.011).

Conclusions: Previous treatment with DOACs and DOACs treatment during admission seem to have a protective role in patients with atrial fibrillation, although this fact should be verified in prospective studies.

Keywords: Anticoagulación; Anticoagulation; Atrial fibrillation; COVID-19; Factor de riesgo; Fibrilación auricular; Hospitalización; Hospitalization; Mortalidad; Mortality; Risk factor.

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Comment in

  • Direct oral anticoagulants (DOAC) for patients with atrial fibrillation during the COVID-19 pandemic.
    Kow CS, Ramachandram DS, Hasan SS. Kow CS, et al. Med Clin (Barc). 2022 Nov 11;159(9):e61. doi: 10.1016/j.medcli.2022.05.016. Epub 2022 Jul 20. Med Clin (Barc). 2022. PMID: 35933189 Free PMC article. No abstract available.
  • Reply.
    Méndez Bailón M, Azaña Gómez J, Pérez Belmonte L. Méndez Bailón M, et al. Med Clin (Barc). 2022 Nov 11;159(9):e62. doi: 10.1016/j.medcli.2022.06.002. Epub 2022 Aug 16. Med Clin (Barc). 2022. PMID: 35985894 Free PMC article. English, Spanish. No abstract available.

References

    1. Word Health Organization. Novel coronavirus – China. 2020 [consultado 21 Sept 2021]. Disponible en: http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/
    1. Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). COVID-19 Dashboard. 2020 [consultado 9 Ene 2022]. Disponible en: https://gisanddata.maps.arcgis. com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6
    1. Ramos-Rincon J.M., Buonaiuto V., Ricci M., Martín-Carmona J., Paredes-Ruíz D., Calderón-Moreno M., et al. SEMI-COVID-19 Network. Clinical characteristics and risk factors for mortality in very old patients hospitalized with COVID-19 in Spain. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76:28–37. - PMC - PubMed
    1. Harrison S.L., Fazio-Eynullayeva E., Lane D.A., Underhill P., Lip G.Y. Atrial fibrillation and the risk of 30-day incident thromboembolic events, and mortality in adults ≥ 50 years with COVID-19. J Arrhythm. 2020;11:231–237. - PMC - PubMed
    1. Wallentin L., Lindbäck J., Eriksson N., Hijazi Z., Eikelboom J.W., Ezekowitz M.D., et al. Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. Eur Heart J. 2020;1:4037–4046. - PMC - PubMed

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