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. 2022 Feb 25:14:829098.
doi: 10.3389/fnagi.2022.829098. eCollection 2022.

Delirium-Onset of Prodromal Dementia With Lewy Bodies-Putative Brainstem-Related Pathomechanism and Clinical Relevance

Niels Hansen  1 , Charles Timäus  1 , Caroline Bouter  2 , Claudia Lange  1 , Katharina Packroß  1
Affiliations

Delirium-Onset of Prodromal Dementia With Lewy Bodies-Putative Brainstem-Related Pathomechanism and Clinical Relevance

Niels Hansen et al. Front Aging Neurosci. .
No abstract available

Keywords: alpha-synuclein; delirium; locus coeruleus; noradrenaline; prodromal dementia with Lewy bodies.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Proposed brainstem predominant pathologies in prodromal DLB's delirium onset. There is controversy about whether neuropathology starts in the enteric nervous system (ENS) as first-body pathology or in the brain such as in the olfactory bulb (OB) or brainstem. However, postulating a brainstem-type of Lewy body pathology in prodromal DLB with delirium, we propose Lewy body pathology and degeneration affecting the spinal cord (SC), dorsal motor nucleus of the vagus nerve (DNV), magnocellular reticular formation (RF), lower raphe nuclei (LRN), and the locus coeruleus (LC). The substantia nigra (SN) is more likely to be affected later than the LC.
See this image and copyright information in PMC

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