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. 2022 Feb 25:9:797811.
doi: 10.3389/fsurg.2022.797811. eCollection 2022.

The Correlation Between Intra-Abdominal Pressure and Tolerance to Postoperative Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei

Junye Yu  1 , Lifei Yu  2 , Lin Su  3 , Ying Shi  4
Affiliations

The Correlation Between Intra-Abdominal Pressure and Tolerance to Postoperative Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei

Junye Yu et al. Front Surg. .

Abstract

Objective: To evaluate the correlation between pain intensity and comfort level in patients with pseudomyxoma peritoneum (PMP) before and after hyperthermic intraperitoneal chemotherapy (HIPEC).

Methods: From June 2018 to June 2019, patients who underwent HIPEC for PMP after surgical treatment in our institute were selected. The intra-abdominal pressure (IAP) and pain intensity (PI) before and after HIPEC were recorded, and the correlation between them was analyzed.

Results: Seventy-four patients received HIPEC 253 times. IAP and PI were significantly higher after perfusion than before perfusion (P < 0.05). When IAP < 12 cmH2O, the change of PI was not correlated to the increase of IAP, and the patient tolerated the treatment. However, when IAP > 12 cmH2O, the increase of PI was significantly associated with IAP and cause significant discomfort during the treatment.

Conclusion: IAP may be a monitoring index for the comfort of PMP patients during the postoperative HIPEC treatment.

Keywords: comfort assessment; intra-abdominal pressure; postoperative hyperthermic intraperitoneal chemotherapy; pseudomyxoma peritonei; surgical oncology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
IAPs measured by transabdominal and transvesical method before (A) and after (B) perfusion.
Figure 2
Figure 2
Pressure distribution in the abdominal cavity before and after perfusion.
Figure 3
Figure 3
Distribution of pain score before and after perfusion.
Figure 4
Figure 4
Forest diagram of the relationship between IAP and PI after perfusion.
See this image and copyright information in PMC

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