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Editorial
. 2022 Feb;11(1):100-102.
doi: 10.21037/hbsn-21-421.

Extracellular vesicles small RNA clusters: hit the nail on the head of liver cancer detection

Affiliations
Editorial

Extracellular vesicles small RNA clusters: hit the nail on the head of liver cancer detection

Artur Słomka et al. Hepatobiliary Surg Nutr. 2022 Feb.
No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-21-421/coif). VLK and MTK report grant from DFG, German Research Foundation. The other authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
A simplified concept of the use of liquid biopsy in clinical oncology proposed by von Felden et al. (7). Thanks to innovative laboratory methods and IT technologies, it is possible to accurately and sensitively screen and diagnose liver cancers and assess their progression. Evaluation of EVs in readily available samples of biological material and analysis of results with AI can become part of personalized medicine, and replace the standard solid biopsy. EVs, extracellular vesicles; AI, artificial intelligence.

Comment on

  • Unannotated small RNA clusters associated with circulating extracellular vesicles detect early stage liver cancer.
    von Felden J, Garcia-Lezana T, Dogra N, Gonzalez-Kozlova E, Ahsen ME, Craig A, Gifford S, Wunsch B, Smith JT, Kim S, Diaz JEL, Chen X, Labgaa I, Haber P, Olsen R, Han D, Restrepo P, D'Avola D, Hernandez-Meza G, Allette K, Sebra R, Saberi B, Tabrizian P, Asgharpour A, Dieterich D, Llovet JM, Cordon-Cardo C, Tewari A, Schwartz M, Stolovitzky G, Losic B, Villanueva A. von Felden J, et al. Gut. 2021 Jul 28:gutjnl-2021-325036. doi: 10.1136/gutjnl-2021-325036. Online ahead of print. Gut. 2021. PMID: 34321221 Free PMC article.

References

    1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49. 10.3322/caac.21660 - DOI - PubMed
    1. Mocan T, Simão AL, Castro RE, et al. Liquid Biopsies in Hepatocellular Carcinoma: Are We Winning? J Clin Med 2020;9:1541. 10.3390/jcm9051541 - DOI - PMC - PubMed
    1. Urban SK, Mocan T, Sänger H, et al. Extracellular Vesicles in Liver Diseases: Diagnostic, Prognostic, and Therapeutic Application. Semin Liver Dis 2019;39:70-7. 10.1055/s-0038-1676122 - DOI - PubMed
    1. Julich-Haertel H, Urban SK, Krawczyk M, et al. Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma. J Hepatol 2017;67:282-92. 10.1016/j.jhep.2017.02.024 - DOI - PubMed
    1. Urban SK, Sänger H, Krawczyk M, et al. Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation. Liver Int 2020;40:3103-16. 10.1111/liv.14585 - DOI - PubMed