Diagnostic accuracy of the ultrasensitive S-PLEX SARS-CoV-2 N electrochemiluminescence immunoassay

doi:10.1515/cclm-2022-0155

Comment

. 2022 Mar 14;60(6):e121-e124.

doi: 10.1515/cclm-2022-0155. Print 2022 May 25.

Diagnostic accuracy of the ultrasensitive S-PLEX SARS-CoV-2 N electrochemiluminescence immunoassay

Giuseppe Lippi^{1

2}, Brandon M Henry^{1

3

4}, Martina Montagnana², Mario Plebani⁵

Affiliations

¹ IFCC Task Force on COVID-19, Milan, Italy.
² Section of Clinical Biochemistry, University of Verona, Verona, Italy.
³ Clinical Laboratory, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
⁴ Disease Intervention & Prevention and Population Health Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.
⁵ Department of Medicine-DIMED, University of Padova, Padua, Italy.

PMID: 35285218
DOI: 10.1515/cclm-2022-0155

Free article

Comment

Diagnostic accuracy of the ultrasensitive S-PLEX SARS-CoV-2 N electrochemiluminescence immunoassay

Giuseppe Lippi et al. Clin Chem Lab Med. 2022.

Free article

. 2022 Mar 14;60(6):e121-e124.

doi: 10.1515/cclm-2022-0155. Print 2022 May 25.

Authors

Giuseppe Lippi^{1

2}, Brandon M Henry^{1

3

4}, Martina Montagnana², Mario Plebani⁵

Affiliations

¹ IFCC Task Force on COVID-19, Milan, Italy.
² Section of Clinical Biochemistry, University of Verona, Verona, Italy.
³ Clinical Laboratory, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
⁴ Disease Intervention & Prevention and Population Health Programs, Texas Biomedical Research Institute, San Antonio, TX, USA.
⁵ Department of Medicine-DIMED, University of Padova, Padua, Italy.

PMID: 35285218
DOI: 10.1515/cclm-2022-0155

No abstract available

Keywords: COVID-19; SARS-CoV-2; antigen; diagnosis; immunoassay.

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Ultrasensitive assay for saliva-based SARS-CoV-2 antigen detection.
Ren A, Sohaei D, Ulndreaj A, Pons-Belda OD, Fernandez-Uriarte A, Zacharioudakis I, Sigal GB, Stengelin M, Mathew A, Campbell C, Padmanabhan N, Romero D, Joe J, Soosaipillai A, Kulasingam V, Mazzulli T, Li XA, McGeer A, Diamandis EP, Prassas I. Ren A, et al. Clin Chem Lab Med. 2022 Feb 16;60(5):771-777. doi: 10.1515/cclm-2021-1142. Print 2022 Apr 26. Clin Chem Lab Med. 2022. PMID: 35170269

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References

1. Ren, A, Sohaei, D, Ulndreaj, A, Pons-Belda, OD, Fernandez-Uriarte, A, Zacharioudakis, I, et al.. Ultrasensitive assay for saliva-based SARS-CoV-2 antigen detection. Clin Chem Lab Med 2022;60:771–7. https://doi.org/10.1515/cclm-2021-1142.
1. Pollock, NR, Savage, TJ, Wardell, H, Lee, RA, Mathew, A, Stengelin, M, et al.. Correlation of SARS-CoV-2 nucleocapsid antigen and RNA concentrations in nasopharyngeal samples from children and adults using an ultrasensitive and quantitative antigen assay. J Clin Microbiol 2021;59:e03077–20. https://doi.org/10.1128/JCM.03077-20.
1. Zamora, J, Abraira, V, Muriel, A, Khan, KS, Coomarasamy, A. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol 2006;6:31. https://doi.org/10.1186/1471-2288-6-31.
1. Wang, H, Hogan, CA, Verghese, M, Solis, D, Sibai, M, Huang, C, et al.. SARS-CoV-2 nucleocapsid plasma antigen for diagnosis and monitoring of COVID-19. Clin Chem 2021;68:204–13. https://doi.org/10.1093/clinchem/hvab216.
1. Wang, H, Hogan, CA, Verghese, M, Solis, D, Sibai, M, Huang, C, et al.. Ultra-sensitive Severe acute respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antigen detection for the diagnosis of Coronavirus disease 2019 (COVID-19) in upper respiratory samples. Clin Infect Dis 2021;73:2326–8. https://doi.org/10.1093/cid/ciab063.

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[1] Ren, A, Sohaei, D, Ulndreaj, A, Pons-Belda, OD, Fernandez-Uriarte, A, Zacharioudakis, I, et al.. Ultrasensitive assay for saliva-based SARS-CoV-2 antigen detection. Clin Chem Lab Med 2022;60:771–7. https://doi.org/10.1515/cclm-2021-1142.

[2] Ren, A, Sohaei, D, Ulndreaj, A, Pons-Belda, OD, Fernandez-Uriarte, A, Zacharioudakis, I, et al.. Ultrasensitive assay for saliva-based SARS-CoV-2 antigen detection. Clin Chem Lab Med 2022;60:771–7. https://doi.org/10.1515/cclm-2021-1142.

[3] Pollock, NR, Savage, TJ, Wardell, H, Lee, RA, Mathew, A, Stengelin, M, et al.. Correlation of SARS-CoV-2 nucleocapsid antigen and RNA concentrations in nasopharyngeal samples from children and adults using an ultrasensitive and quantitative antigen assay. J Clin Microbiol 2021;59:e03077–20. https://doi.org/10.1128/JCM.03077-20.

[4] Pollock, NR, Savage, TJ, Wardell, H, Lee, RA, Mathew, A, Stengelin, M, et al.. Correlation of SARS-CoV-2 nucleocapsid antigen and RNA concentrations in nasopharyngeal samples from children and adults using an ultrasensitive and quantitative antigen assay. J Clin Microbiol 2021;59:e03077–20. https://doi.org/10.1128/JCM.03077-20.

[5] Zamora, J, Abraira, V, Muriel, A, Khan, KS, Coomarasamy, A. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol 2006;6:31. https://doi.org/10.1186/1471-2288-6-31.

[6] Zamora, J, Abraira, V, Muriel, A, Khan, KS, Coomarasamy, A. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol 2006;6:31. https://doi.org/10.1186/1471-2288-6-31.

[7] Wang, H, Hogan, CA, Verghese, M, Solis, D, Sibai, M, Huang, C, et al.. SARS-CoV-2 nucleocapsid plasma antigen for diagnosis and monitoring of COVID-19. Clin Chem 2021;68:204–13. https://doi.org/10.1093/clinchem/hvab216.

[8] Wang, H, Hogan, CA, Verghese, M, Solis, D, Sibai, M, Huang, C, et al.. SARS-CoV-2 nucleocapsid plasma antigen for diagnosis and monitoring of COVID-19. Clin Chem 2021;68:204–13. https://doi.org/10.1093/clinchem/hvab216.

[9] Wang, H, Hogan, CA, Verghese, M, Solis, D, Sibai, M, Huang, C, et al.. Ultra-sensitive Severe acute respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antigen detection for the diagnosis of Coronavirus disease 2019 (COVID-19) in upper respiratory samples. Clin Infect Dis 2021;73:2326–8. https://doi.org/10.1093/cid/ciab063.

[10] Wang, H, Hogan, CA, Verghese, M, Solis, D, Sibai, M, Huang, C, et al.. Ultra-sensitive Severe acute respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antigen detection for the diagnosis of Coronavirus disease 2019 (COVID-19) in upper respiratory samples. Clin Infect Dis 2021;73:2326–8. https://doi.org/10.1093/cid/ciab063.

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Diagnostic accuracy of the ultrasensitive S-PLEX SARS-CoV-2 N electrochemiluminescence immunoassay

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Diagnostic accuracy of the ultrasensitive S-PLEX SARS-CoV-2 N electrochemiluminescence immunoassay

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