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Editorial
. 2022 May;66(5):473-475.
doi: 10.1165/rcmb.2022-0029ED.

Long Noncoding RNAs: Emerging Regulators of Platelet-derived Growth Factor Signaling

Chanil Valasarajan  1 , Annika Karger  1 , Rajkumar Savai  1   2   3 , Soni S Pullamsetti  1   2   3
Affiliations
Editorial

Long Noncoding RNAs: Emerging Regulators of Platelet-derived Growth Factor Signaling

Chanil Valasarajan et al. Am J Respir Cell Mol Biol. 2022 May.
No abstract available

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Figures

Figure 1.
Figure 1.
LncPTSR in vascular remodeling of pulmonary hypertension. (A) Enhanced platelet-derived growth factor (PDGF)-BB signaling in pulmonary hypertension (PH) represses expression of lncPTSR through the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) pathway. When downregulated, PMCA4 expression is no longer enhanced through the nucleus-located lncPTSR, leading to reduced amounts of PMCA4 and increased intracellular Ca2+, thereby regulating RPASMC proliferation and migration. (B) LncPTSR is targeted in an in vivo rat PH model via AAV9 particle-mediated shRNA delivery. RNA therapeutics still face several issues, such as RNA stability, dose control, efficacy, consistency, and off-target effects. AAV9 = adeno-associated virus 9; RPASMC = rat pulmonary arterial smooth muscle cells.
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