Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 May;18(5):343-349.
doi: 10.1007/s12519-022-00529-1. Epub 2022 Mar 14.

Analysis of clinical characteristics of 66 pediatric patients with B.1.617.2 (Delta) variant of COVID-19

Affiliations

Analysis of clinical characteristics of 66 pediatric patients with B.1.617.2 (Delta) variant of COVID-19

Jing Hao et al. World J Pediatr. 2022 May.

Erratum in

Abstract

Background: The aim of this study was to analyze the clinical characteristics of 66 pediatric patients with B.1.617.2 (Delta) variant of coronavirus disease 2019 (COVID-19).

Methods: Sixty-six pediatric patients with B.1.617.2 (Delta) variant of COVID-19 admitted to the hospital from July to August 2021 were classified into mild (n = 41) and moderate groups (n = 25). Clinical characteristics, laboratory data and dynamic trends in different time periods were analyzed retrospectively.

Results: There were no statistically significant differences in age, gender ratios and clinical symptoms between the mild group and the moderate group. All the patients in the moderate group had clusters of onsets, and the incubation period was shorter than that of the mild group. Within 24 hours of admission, the levels of erythrocyte sedimentation rate, cardiac troponin I, D-dimer in the moderate group were higher than that in the mild group (P < 0.05). The titers of immunoglobulin (Ig) G and IgM antibodies gradually increased after disease onset. Thirty-five (53.03%) children were tested positive for antibodies in 4-12 days. IgG increased gradually, while IgM decreased obviously in about 15 days after disease onset. The cycle threshold values of open reading frame 1ab and nucleocapsid protein gene in the severe acute respiratory syndrome coronavirus 2 genomes increased gradually on the 3rd, 6th, 9th, and 12th days after disease onset, compared with those in day 0.

Conclusions: The symptoms of children with B.1.617.2 (Delta) variant of COVID-19 were mild. The description and analysis of the clinical characteristics and laboratory data can help medical staff to evaluate the condition of children with COVID-19 and to accumulate more clinical experience.

Keywords: B.1.617.2 (Delta); Children; Clinical features; Coronavirus disease 2019 (COVID-19).

PubMed Disclaimer

Conflict of interest statement

Author GXH is a member of the Editorial Board for the World Journal of Pediatrics. The paper was handled by the other Editor and has undergone a rigorous peer-review process. Author GXH was not involved in the journal's review of, or decisions related to, this manuscript. The authors have no conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Clinical symptoms of 66 pediatric patients with coronavirus disease 2019. a Mild group (n = 41); b moderate group (n = 25)
Fig. 2
Fig. 2
The dynamic trend of immunoglobulin (Ig) M and IgG antibodies levels in pediatric patients with coronavirus disease 2019 (n = 66)
Fig. 3
Fig. 3
The results of polymerase chain reaction showed variation tendency of N and ORF1ab genes at a different time of both mild and moderate groups. a Ct values of N gene compared to day 0; b Ct values of ORF1ab gene compared to day 0. For both groups of the two genes, 3rd day vs. day 0, no significant statistical difference; 6th, 9th, and 12th days vs. day 0, P < 0.001. Ct cycle threshold, N nucleocapsid protein gene, ORF1ab open reading frame 1ab gene

References

    1. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–513. doi: 10.1016/S0140-6736(20)30211-7. - DOI - PMC - PubMed
    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
    1. Adam D. What scientists know about new, fast-spreading coronavirus variants. Nature. 2021;594:19–20. doi: 10.1038/d41586-021-01390-4. - DOI - PubMed
    1. Reis BY, Barda N, Leshchinsky M, Kepten E, Hernán MA, Lipsitch M, et al. Effectiveness of BNT162b2 vaccine against Delta variant in adolescents. N Engl J Med. 2021;385:2101–2103. doi: 10.1056/NEJMc2114290. - DOI - PMC - PubMed
    1. Elbe S, Buckland-Merrett G. Data, disease and diplomacy: GISAID's innovative contribution to global health. Glob Chall. 2017;1:33–46. doi: 10.1002/gch2.1018. - DOI - PMC - PubMed

Supplementary concepts