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Randomized Controlled Trial
. 2022 Mar 14;22(1):201.
doi: 10.1186/s12884-022-04530-4.

Safety and efficacy of preoperative tranexamic acid in reducing intraoperative and postoperative blood loss in high-risk women undergoing cesarean delivery: a randomized controlled trial

Mohamed A Shalaby  1 , Ahmed M Maged  2 , Amira Al-Asmar  2 , Mohamed El Mahy  2 , Maged Al-Mohamady  2 , Nancy Mohamed Ali Rund  3
Affiliations
Randomized Controlled Trial

Safety and efficacy of preoperative tranexamic acid in reducing intraoperative and postoperative blood loss in high-risk women undergoing cesarean delivery: a randomized controlled trial

Mohamed A Shalaby et al. BMC Pregnancy Childbirth. .

Erratum in

Abstract

Background: Objective to assess the value of preoperative tranexamic acid (TXA) in reduction of intraoperative and postoperative blood loss in high-risk cesarean delivery (CD).

Methods: A double blind randomized controlled trial included 160 high risk women who underwent elective lower segment CD. They were equally randomized to receive either 1 g of TXA or placebo 15 min before surgery. The primary outcome was Intraoperative blood loss.

Results: The estimated blood loss was significantly higher in the placebo group when compared to TXA group (896.81 ± 519.6 vs. 583.23 ± 379.62 ml, P < 0.001). Both postoperative hemoglobin and hematocrit were lower (9.2 ± 1.6 and 27.4 ± 4.1 vs. 10.1 ± 1.2 and 30.1 ± 3.4, P values < 0.001and 0.012 respectively) and their change percentages (15.41 vs. 7.11%, P < 0.001) were higher in the placebo group when compared to TXA one. The need for further ecbolics was higher in placebo group when compared to TXA group (46.25 vs. 13.75%, P < 0.001).

Conclusion: Preoperative TXA is safe and effective in reducing blood loss during and after high-risk CD.

Trial registration: ClincalTrial.gov ID: NCT03820206 .

Keywords: Elective CS; High risk CS; Intraoperative blood loss; Postpartum hemorrhage; Tranexamic acid.

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Conflict of interest statement

All authors report that there is no competing interests in this work.

Figures

Fig. 1
Fig. 1
Consort flow chart
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References

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