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. 2022 May:504:113246.
doi: 10.1016/j.jim.2022.113246. Epub 2022 Mar 11.

ZIKV B-cell epitopes for immunodiagnostic tests

Janaina Rigotti Kubiszeski  1 , David José Ferreira da Silva  1 , Gabriela de Lima Menezes  2 , Roosevelt Alves da Silva  2 , Nathalia Zini  3 , Maurício Lacerda Nogueira  3 , Lindomar José Pena  4 , Julia Pinto Piccoli  5 , Eduardo Maffud Cilli  5 , Joaquim Manoel da Silva  6 , Roberta Vieira de Morais Bronzoni  7
Affiliations

ZIKV B-cell epitopes for immunodiagnostic tests

Janaina Rigotti Kubiszeski et al. J Immunol Methods. 2022 May.

Abstract

The use of serological tests is valuable to diagnose Zika virus (ZIKV) infection and carry out epidemiological surveillance. However, ZIKV serological tests may result in false positives due to cross-reactivity between antibodies against other Flavivirus, especially dengue virus that worldwide disseminated. We used three online tools to predict amino acid sequences of B-cell epitopes. We selected and synthetized two epitopes that showed appropriate features in the molecular dynamic simulation and demonstrated to be suitable for serological assays.

Keywords: Arbovirus; Bioinformatics; Immunoassay; Peptide.

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