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. 2022 Aug;24(8):1351-1361.
doi: 10.1016/j.hpb.2022.02.006. Epub 2022 Feb 28.

Association of primary tumor laterality with surgical outcomes for colorectal liver metastases: results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC)

Cristian D Valenzuela  1 , Omeed Moaven  2 , Rohin Gawdi  1 , John A Stauffer  3 , Nico R Del Piccolo  3 , Tan To Cheung  4 , Carlos U Corvera  5 , Andrew D Wisneski  5 , Charles Cha  6 , Christopher W Mangieri  1 , Nima P Zarandi  1 , Justin Dourado  1 , Kathleen C Perry  1 , Gregory Russell  7 , Perry Shen  8
Affiliations

Association of primary tumor laterality with surgical outcomes for colorectal liver metastases: results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC)

Cristian D Valenzuela et al. HPB (Oxford). 2022 Aug.

Abstract

Background: Primary laterality of colorectal cancer is thought to be associated with differences in outcomes. Liver metastasis is the most common site of solitary colorectal cancer spread. However, how primary colorectal cancer laterality affects outcomes in colorectal liver metastasis remains unclear.

Methods: The Colorectal Liver Operative Metastasis International Collaborative (COLOMIC) of operative hepatectomy cases for colorectal liver metastasis was compiled from five participating institutions. This included consecutive cases from 2000 to 2018 at all sites. A total of 884 patients were included in this study. Univariate, multivariate, and Kaplan-Meier analyses were performed.

Results: Patients with left-sided versus right-sided cancers had significantly better overall survival: 49.4 vs. 41.8 months (p < 0.05). Patients with KRAS mutations had significantly worse median overall survival compared to KRAS wild-type (43.6 vs 56.1 months; p < 0.001). In left-sided cancers, KRAS mutations were associated with significantly worse median overall survival compared to KRAS wild-type cancers (43.6 vs 56.6 months; p < 0.01). This association was absent in patients with right-sided primary tumors. Multivariate Cox regression analysis revealed different variable sets (non-overlapping) were associated with overall survival, when comparing left-sided and right-sided cancers.

Conclusion: Understanding how primary tumor laterality and related biological aspects affect long-term outcomes can potentially inform treatment decisions for patients with colorectal liver metastases.

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Conflict of interest statement

Declaration of interests

☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Overall survival after hepatectomy for colorectal liver metastasis, by laterality of primary colorectal cancer
Figure 2
Figure 2
a. Overall survival after hepatectomy for CLM, by KRAS status. b. Overall survival after hepatectomy for CLM for left-sided colorectal cancers, by KRAS status. c. Overall survival after hepatectomy for CLM for right-sided colorectal cancers, by KRAS status
Figure 2
Figure 2
a. Overall survival after hepatectomy for CLM, by KRAS status. b. Overall survival after hepatectomy for CLM for left-sided colorectal cancers, by KRAS status. c. Overall survival after hepatectomy for CLM for right-sided colorectal cancers, by KRAS status
Figure 2
Figure 2
a. Overall survival after hepatectomy for CLM, by KRAS status. b. Overall survival after hepatectomy for CLM for left-sided colorectal cancers, by KRAS status. c. Overall survival after hepatectomy for CLM for right-sided colorectal cancers, by KRAS status
See this image and copyright information in PMC

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