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Comment
. 2022 Jul;52(7):e13764.
doi: 10.1111/eci.13764. Epub 2022 Mar 15.

Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore

Giampaolo Morciano  1   2 , Gaia Pedriali  2 , Elisa Mikus  3 , Paolo Cimaglia  2 , Simone Calvi  3 , Rita Pavasini  4 , Alberto Albertini  3 , Roberto Ferrari  2 , Mariusz R Wieckowski  5 , Carlotta Giorgi  1 , Gianluca Campo  4 , Paolo Pinton  1   2
Affiliations
Comment

Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore

Giampaolo Morciano et al. Eur J Clin Invest. 2022 Jul.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Main findings from the CROFT clinical study. (A) Set‐up of the experiments in which TMRM probe is shown to be sensitive to mPTP stimuli and CsA pretreatment in the evaluation of mPTP opening. In the upper panel, images and kinetics of mPTP opening in cardiomyocytes with (w/) and without (w/o) CsA; in the bottom panel, images and kinetics of mPTP opening in fibroblasts in the same conditions. (B) mPTP activity measured with the TMRM probe in both myocytes (red) and fibroblasts (blue) from the same patient. (C) Bland–Altman test: bias =0.15; 95% limits of agreement =dotted lines; Y axis =difference between measures; X axis =average of mPTP measures. (D) Graph showing the correlation (Spearman's r index) between mPTP measured in both myocytes (X axis) and fibroblasts (Y axis) for each patient in the CROFT study. (E) Stratification of mPTP function measured in myocytes (Y axis) according to the median fibroblast mPTP value
See this image and copyright information in PMC

Comment on

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