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. 2022 Aug;13(8):1387-1395.
doi: 10.1111/jdi.13791. Epub 2022 Apr 12.

Factors affecting glycemic control in diabetes mellitus complicated by autoimmune pancreatitis

Nozomi Harai  1   2 , Akihiro Nishimura  1 , Kimio Matsumura  1 , Yuya Suzuki  1 , Shota Kikuno  1 , Tetsuro Kobayashi  1   3 , Kaoru Nagasawa  1 , Yasumichi Mori  1
Affiliations

Factors affecting glycemic control in diabetes mellitus complicated by autoimmune pancreatitis

Nozomi Harai et al. J Diabetes Investig. 2022 Aug.

Abstract

Aims/introduction: To investigate factors influencing glycemic control in diabetes mellitus complicated by autoimmune pancreatitis.

Materials and methods: This retrospective cohort study investigated 33 patients with diabetes mellitus complicated by autoimmune pancreatitis who had received steroid therapy at Toranomon Hospital between January 1, 2011, and December 31, 2020. The course of glycemic control at 12 months after starting steroids was classified into three groups: Improved, Unchanged, or Worsened. Factors affecting these groups were investigated. Furthermore, we created two scores: (1) time of diabetes mellitus onset and baseline body mass index; (2) time of diabetes mellitus onset and baseline C-peptide index. Diabetes mellitus occurring at the same time as autoimmune pancreatitis, body mass index ≥22 kg/m2 , and C-peptide index ≥1.1 were each worth 1 point. Scores were summed and totals of 0-2 were compared between groups.

Results: Ten patients were in the Improved group, 10 were in the Unchanged group, and 13 were in the Worsened group. The baseline body mass index and baseline C-peptide index were lower in the Worsened group than in the Improved group (P < 0.05 each). In addition, the scores were lower in the Worsened group than in the other groups (P < 0.05).

Conclusions: Patients with a lower baseline body mass index and a decreased baseline C-peptide index may experience worse glycemic control on steroid therapy.

Keywords: Autoimmune pancreatitis; Diabetes mellitus; Steroid.

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Figures

Figure 1
Figure 1
(a) Histogram showing the number of patients and score. The score comprising time of onset of diabetes mellitus and baseline BMI. (b) Histogram showing the number of patients and score. The score comprising time of onset of diabetes mellitus and baseline CPI.
Figure 2
Figure 2
(a) Box plot showing a comparison of scores comprising time of onset of diabetes mellitus and baseline BMI. The lower and upper boxes of the box represent the 25th and 75th percentile values, respectively. The horizontal line in the center of the box represents the median. The cross mark represents the mean. (b) Box plot showing a comparison of scores comprising time of onset of diabetes mellitus and baseline CPI. The lower and upper boxes of the box represent the 25th and 75th percentile values, respectively. The horizontal line in the center of the box represents the median. The cross mark represents the mean.
Figure 3
Figure 3
Correlation between baseline BMI and baseline CPI (r = 0.468, P = 0.029).
See this image and copyright information in PMC

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