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. 2022 Mar 14;8(1):00588-2021.
doi: 10.1183/23120541.00588-2021. eCollection 2022 Jan.

Impact of lockdown during the COVID-19 pandemic on health status in patients with cystic fibrosis: a mono-centre observational study

Stephanie Thee  1 , Leonie Marie Busack  1 , Marcus A Mall  1   2   3   4 , Mirjam Stahl  1   2   3   4
Affiliations

Impact of lockdown during the COVID-19 pandemic on health status in patients with cystic fibrosis: a mono-centre observational study

Stephanie Thee et al. ERJ Open Res. .

Abstract

FEV1 % predicted decreased substantially in paediatric patients with #cysticfibrosis during the first lockdown of the ongoing #SARSCoV2 pandemic in Germany. More information on consequences of repetitive shutdowns in people with cystic fibrosis is needed. https://bit.ly/3fZwuIb.

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Conflict of interest statement

Conflict of interest: S. Thee has nothing to diclose. Conflict of interest: L.M. Busack has nothing to diclose. Conflict of interest: M. Mall reports grants from the German Federal Ministry of Education and Research during the conduct of the study; personal fees and other support from Boehringer Ingelheim, personal fees from Arrowhead Pharmaceuticals, personal fees and other support from Vertex Pharmaceuticals, and personal fees from Santhera, Sterna Biologicals, Enterprise Therapeutics, Antabio, Kither Biotech and Prieris Pharmaceuticals, outside the submitted work. Conflict of interest: M. Stahl declares grants or contracts from the German Cystic Fibrosis Association Mukoviszidose e.V., Vertex Pharmaceuticals, Charité – Universitätsmedizin Berlin and the BIH, in the 36 months prior to manuscript submission.

Figures

FIGURE 1
FIGURE 1
Comparison of change of lung function parameters in patients with cystic fibrosis over the lockdown period and over a comparable time period in the year before the pandemic in a, b) the entire study group, according to c, d) age group (<18 years of age and ≥18 years of age) and e, f) Pseudomonas aeruginosa (Psa) infection status (patients chronically and not chronically infected with Psa). Changes in forced expiratory volume in 1 s (FEV1) % predicted and forced vital capacity (FVC) % predicted are displayed as means and 95% confidence intervals.
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