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Editorial
. 2022 Feb 3;13(3):330-331.
doi: 10.1021/acsmedchemlett.2c00030. eCollection 2022 Mar 10.

Novel Nitrile Peptidomimetics for Treating COVID-19

C S Brian Chia  1
Affiliations
Editorial

Novel Nitrile Peptidomimetics for Treating COVID-19

C S Brian Chia. ACS Med Chem Lett. .

Abstract

COVID-19 is a highly infectious disease caused by the viral pathogen SARS-CoV-2, causing an estimated 5.4 million fatalities globally in 2 years since its emergence in December 2019. On December 22, 2021, the U.S. FDA granted Emergency Use Authorization for the oral viral main protease inhibitor, Nirmatrelvir, to treat patients with mild-to-moderate COVID-19. This patent review reveals the structure-activity relationship of key inhibitors described in the patent WO 2021/250648 A1.

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Conflict of interest statement

The author declares no competing financial interest.

References

    1. Drug Discov Today. 2021 Mar;26(3):804-816 - PubMed
    1. Science. 2021 Dec 24;374(6575):1586-1593 - PubMed

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