HCV cure: an appropriate moment to reduce cannabis use in people living with HIV? (ANRS CO13 HEPAVIH data)

doi:10.1186/s12981-022-00440-9

. 2022 Mar 15;19(1):15.

doi: 10.1186/s12981-022-00440-9.

HCV cure: an appropriate moment to reduce cannabis use in people living with HIV? (ANRS CO13 HEPAVIH data)

Collaborators, Affiliations

Collaborators

ANRS CO13 HEPAVIH Study Group:
D Salmon, L Wittkop, P Sogni, L Esterle, P Trimoulet, J Izopet, L Serfaty, V Paradis, B Spire, P Carrieri, M A Valantin, G Pialoux, J Chas, I Poizot-Martin, K Barange, A Naqvi, E Rosenthal, A Bicart-See, O Bouchaud, A Gervais, C Lascoux-Combe, C Goujard, K Lacombe, C Duvivier, D Neau, P Morlat, F Bani-Sadr, L Meyer, F Boufassa, B Autran, A M Roque, C Solas, H Fontaine, D Costagliola, L Piroth, A Simon, D Zucman, F Boué, P Miailhes, E Billaud, H Aumaître, D Rey, G Peytavin, V Petrov-Sanchez, A Levier, R Usubillaga, B Terris, P Tremeaux, C Katlama, M A Valantin, H Stitou, P Cacoub, S Nafissa, Y Benhamou, F Charlotte, S Fourati, O Zaegel, H Laroche, C Tamalet, P Callard, F Bendjaballah, C Le Pendeven, B Marchou, L Alric, S Metivier, J Selves, F Larroquette, V Rio, J Haudebourg, M C Saint-Paul, A De Monte, V Giordanengo, C Partouche, A Martin, M Ziol, Y Baazia, V Iwaka-Bande, A Gerber, M Uzan, D Garipuy, M J Ferro-Collados, F Nicot, Y Yazdanpanah, H Adle-Biassette, G Alexandre, J M Molina, P Bertheau, M L Chaix, C Delaugerre, S Maylin, J Bottero, J Krause, P M Girard, D Wendum, P Cervera, J Adam, C Viala, D Vittecocq, Y Quertainmont, E Teicher, C Pallier, O Lortholary, C Rouzaud, J Lourenco, F Touam, C Louisin, V Avettand-Fenoel, E Gardiennet, A Mélard, A Ochoa, E Blanchard, S Castet-Lafarie, C Cazanave, D Malvy, M Dupon, H Dutronc, F Dauchy, L Lacaze-Buzy, A Desclaux, P Bioulac-Sage, S Reigadas, D Lacoste, F Bonnet, N Bernard, M Hessamfar, J, F Paccalin, C Martell, M C Pertusa, M Vandenhende, P Mercié, T Pistone, M C Receveur, M Méchain, P Duffau, C Rivoisy, I Faure, S Caldato, P Bellecave, C Tumiotto, J L Pellegrin, J F Viallard, E Lazzaro, C Greib, C Majerholc, M Brollo, E Farfour, J Polo Devoto, I Kansau, V Chambrin, C Pignon, L Berroukeche, R Fior, V Martinez, S Abgrall, M Favier, C Deback, Y Lévy, S Dominguez, J D Lelièvre, A S Lascaux, G Melica, F Raffi, C Allavena, V Reliquet, D Boutoille, C Biron, M Lefebvre, N Hall, S Bouchez, A Rodallec, L Le Guen, C Hemon, D Peyramond, C Chidiac, F Ader, F Biron, A Boibieux, L Cotte, T Ferry, T Perpoint, J Koffi, F Zoulim, F Bailly, P Lack, M Maynard, S Radenne, M Amiri, F Valour, C Augustin-Normand, C Scholtes, T T Le-Thi, P Chavanet M Duong Van Huyen, M Buisson, A Waldner-Combernoux, S Mahy, A Salmon Rousseau, C Martins, S Galim, D Lambert, Y Nguyen, J L Berger, M Hentzien, V Brodard, M Partisani, M L Batard, C Cheneau, M Priester, C Bernard-Henry, E de Mautort, P Fischer, P Gantner, S Fafi-Kremer, F Roustant, P Platterier, I Kmiec, L Traore, S Lepuil, S Parlier, V Sicart-Payssan, E Bedel, S Anriamiandrisoa, C Pomes, M Mole, C Bolliot, P Catalan, M Mebarki, A Adda-Lievin, P Thilbaut, Y Ousidhoum, F Z Makhoukhi, O Braik, R Bayoud, C Gatey, M P Pietri, V Le Baut, R Ben Rayana, D Bornarel, C Chesnel, D Beniken, M Pauchard, S Akel, C Lions, A Ivanova, A-S Ritleg, C Debreux, L Chalal, J Zelie, H Hue, A Soria, M Cavellec, S Breau, A Joulie, P Fisher, S Gohier, D Croisier-Bertin, S Ogoudjobi, C Brochier, V Thoirain-Galvan, M Le Cam, M Chalouni, V Conte, L Dequae-Merchadou, M Desvallees, C Gilbert, S Gillet, R Knight, T Lemboub, F Marcellin, L Michel, M Mora, C Protopopescu, P Roux, S Tezkratt, T Barré, T Rojas Rojas, M Baudoin, M Santos V Di Beo, M Nishimwe

Affiliations

¹ Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 35 boulevard Jean Moulin, 13005, Marseille, France.
² Centre Hospitalier Universitaire (CHU) de Bordeaux, Pôle Médecine Interne, Service de Médecine Interne et Immunologie Clinique, Bordeaux Population Health Research Center UMR 1219, CIC-EC 1401, Université de Bordeaux, Pl. Amélie Raba Léon, 33000, Bordeaux, France.
³ Centre Hospitalier de Bourg-en-Bresse, Service d'Infectiologie, 900 Rte de Paris, 01012, Bourg-en-Bresse, France.
⁴ Réseau Ville-Hôpital, Service de Médecine Interne, Foch Hospital, 40 Rue Worth, 92150, Suresnes, France.
⁵ Centre Hospitalier de Perpignan, Service des Maladies Infectieuses et Tropicales, 20 Av. du Languedoc, 66000, Perpignan, France.
⁶ ISPED, Inserm, Bordeaux Population Health Research Center, Team MORPH3EUS, UMR 1219, CIC-EC 1401, Université de Bordeaux, 146 Rue Léo Saignat 11, Bordeaux, France.
⁷ Université Paris Descartes, 12 Rue de l'École de Médecine, 75006, Paris, France.
⁸ INSERM U1223, Institut Pasteur, 25 rue du Docteur Roux, 75015, Paris, France.
⁹ Hôpital Cochin, 27 Rue du Faubourg Saint-Jacques, 75014, Paris, France.
¹⁰ Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 35 boulevard Jean Moulin, 13005, Marseille, France. pmcarrieri@aol.com.
¹¹ Service Maladies Infectieuses et Tropicales, AP-HP, Hôpital Cochin, 27 Rue du Faubourg Saint-Jacques, 75014, Paris, France.

PMID: 35292069
PMCID: PMC8922772
DOI: 10.1186/s12981-022-00440-9

HCV cure: an appropriate moment to reduce cannabis use in people living with HIV? (ANRS CO13 HEPAVIH data)

Tangui Barré et al. AIDS Res Ther. 2022.

. 2022 Mar 15;19(1):15.

doi: 10.1186/s12981-022-00440-9.

Authors

Collaborators

ANRS CO13 HEPAVIH Study Group:
D Salmon, L Wittkop, P Sogni, L Esterle, P Trimoulet, J Izopet, L Serfaty, V Paradis, B Spire, P Carrieri, M A Valantin, G Pialoux, J Chas, I Poizot-Martin, K Barange, A Naqvi, E Rosenthal, A Bicart-See, O Bouchaud, A Gervais, C Lascoux-Combe, C Goujard, K Lacombe, C Duvivier, D Neau, P Morlat, F Bani-Sadr, L Meyer, F Boufassa, B Autran, A M Roque, C Solas, H Fontaine, D Costagliola, L Piroth, A Simon, D Zucman, F Boué, P Miailhes, E Billaud, H Aumaître, D Rey, G Peytavin, V Petrov-Sanchez, A Levier, R Usubillaga, B Terris, P Tremeaux, C Katlama, M A Valantin, H Stitou, P Cacoub, S Nafissa, Y Benhamou, F Charlotte, S Fourati, O Zaegel, H Laroche, C Tamalet, P Callard, F Bendjaballah, C Le Pendeven, B Marchou, L Alric, S Metivier, J Selves, F Larroquette, V Rio, J Haudebourg, M C Saint-Paul, A De Monte, V Giordanengo, C Partouche, A Martin, M Ziol, Y Baazia, V Iwaka-Bande, A Gerber, M Uzan, D Garipuy, M J Ferro-Collados, F Nicot, Y Yazdanpanah, H Adle-Biassette, G Alexandre, J M Molina, P Bertheau, M L Chaix, C Delaugerre, S Maylin, J Bottero, J Krause, P M Girard, D Wendum, P Cervera, J Adam, C Viala, D Vittecocq, Y Quertainmont, E Teicher, C Pallier, O Lortholary, C Rouzaud, J Lourenco, F Touam, C Louisin, V Avettand-Fenoel, E Gardiennet, A Mélard, A Ochoa, E Blanchard, S Castet-Lafarie, C Cazanave, D Malvy, M Dupon, H Dutronc, F Dauchy, L Lacaze-Buzy, A Desclaux, P Bioulac-Sage, S Reigadas, D Lacoste, F Bonnet, N Bernard, M Hessamfar, J, F Paccalin, C Martell, M C Pertusa, M Vandenhende, P Mercié, T Pistone, M C Receveur, M Méchain, P Duffau, C Rivoisy, I Faure, S Caldato, P Bellecave, C Tumiotto, J L Pellegrin, J F Viallard, E Lazzaro, C Greib, C Majerholc, M Brollo, E Farfour, J Polo Devoto, I Kansau, V Chambrin, C Pignon, L Berroukeche, R Fior, V Martinez, S Abgrall, M Favier, C Deback, Y Lévy, S Dominguez, J D Lelièvre, A S Lascaux, G Melica, F Raffi, C Allavena, V Reliquet, D Boutoille, C Biron, M Lefebvre, N Hall, S Bouchez, A Rodallec, L Le Guen, C Hemon, D Peyramond, C Chidiac, F Ader, F Biron, A Boibieux, L Cotte, T Ferry, T Perpoint, J Koffi, F Zoulim, F Bailly, P Lack, M Maynard, S Radenne, M Amiri, F Valour, C Augustin-Normand, C Scholtes, T T Le-Thi, P Chavanet M Duong Van Huyen, M Buisson, A Waldner-Combernoux, S Mahy, A Salmon Rousseau, C Martins, S Galim, D Lambert, Y Nguyen, J L Berger, M Hentzien, V Brodard, M Partisani, M L Batard, C Cheneau, M Priester, C Bernard-Henry, E de Mautort, P Fischer, P Gantner, S Fafi-Kremer, F Roustant, P Platterier, I Kmiec, L Traore, S Lepuil, S Parlier, V Sicart-Payssan, E Bedel, S Anriamiandrisoa, C Pomes, M Mole, C Bolliot, P Catalan, M Mebarki, A Adda-Lievin, P Thilbaut, Y Ousidhoum, F Z Makhoukhi, O Braik, R Bayoud, C Gatey, M P Pietri, V Le Baut, R Ben Rayana, D Bornarel, C Chesnel, D Beniken, M Pauchard, S Akel, C Lions, A Ivanova, A-S Ritleg, C Debreux, L Chalal, J Zelie, H Hue, A Soria, M Cavellec, S Breau, A Joulie, P Fisher, S Gohier, D Croisier-Bertin, S Ogoudjobi, C Brochier, V Thoirain-Galvan, M Le Cam, M Chalouni, V Conte, L Dequae-Merchadou, M Desvallees, C Gilbert, S Gillet, R Knight, T Lemboub, F Marcellin, L Michel, M Mora, C Protopopescu, P Roux, S Tezkratt, T Barré, T Rojas Rojas, M Baudoin, M Santos V Di Beo, M Nishimwe

Affiliations

¹ Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 35 boulevard Jean Moulin, 13005, Marseille, France.
² Centre Hospitalier Universitaire (CHU) de Bordeaux, Pôle Médecine Interne, Service de Médecine Interne et Immunologie Clinique, Bordeaux Population Health Research Center UMR 1219, CIC-EC 1401, Université de Bordeaux, Pl. Amélie Raba Léon, 33000, Bordeaux, France.
³ Centre Hospitalier de Bourg-en-Bresse, Service d'Infectiologie, 900 Rte de Paris, 01012, Bourg-en-Bresse, France.
⁴ Réseau Ville-Hôpital, Service de Médecine Interne, Foch Hospital, 40 Rue Worth, 92150, Suresnes, France.
⁵ Centre Hospitalier de Perpignan, Service des Maladies Infectieuses et Tropicales, 20 Av. du Languedoc, 66000, Perpignan, France.
⁶ ISPED, Inserm, Bordeaux Population Health Research Center, Team MORPH3EUS, UMR 1219, CIC-EC 1401, Université de Bordeaux, 146 Rue Léo Saignat 11, Bordeaux, France.
⁷ Université Paris Descartes, 12 Rue de l'École de Médecine, 75006, Paris, France.
⁸ INSERM U1223, Institut Pasteur, 25 rue du Docteur Roux, 75015, Paris, France.
⁹ Hôpital Cochin, 27 Rue du Faubourg Saint-Jacques, 75014, Paris, France.
¹⁰ Aix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, ISSPAM, 35 boulevard Jean Moulin, 13005, Marseille, France. pmcarrieri@aol.com.
¹¹ Service Maladies Infectieuses et Tropicales, AP-HP, Hôpital Cochin, 27 Rue du Faubourg Saint-Jacques, 75014, Paris, France.

PMID: 35292069
PMCID: PMC8922772
DOI: 10.1186/s12981-022-00440-9

Abstract

Background: Thanks to direct-acting antivirals, hepatitis C virus (HCV) infection can be cured, with similar rates in HCV-infected and HIV-HCV co-infected patients. HCV cure is likely to foster behavioral changes in psychoactive substance use, which is highly prevalent in people living with HIV (PLWH). Cannabis is one substance that is very commonly used by PLWH, sometimes for therapeutic purposes. We aimed to identify correlates of cannabis use reduction following HCV cure in HIV-HCV co-infected cannabis users and to characterize persons who reduced their use.

Methods: We used data collected on HCV-cured cannabis users in a cross-sectional survey nested in the ANRS CO13 HEPAVIH cohort of HIV-HCV co-infected patients, to perform logistic regression, with post-HCV cure cannabis reduction as the outcome, and socio-behavioral characteristics as potential correlates. We also characterized the study sample by comparing post-cure substance use behaviors between those who reduced their cannabis use and those who did not.

Results: Among 140 HIV-infected cannabis users, 50 and 5 had reduced and increased their use, respectively, while 85 had not changed their use since HCV cure. Cannabis use reduction was significantly associated with tobacco use reduction, a decrease in fatigue level, paying more attention to one's dietary habits since HCV cure, and pre-HCV cure alcohol abstinence (p = 0.063 for alcohol use reduction).

Conclusions: Among PLWH using cannabis, post-HCV cure cannabis reduction was associated with tobacco use reduction, improved well-being, and adoption of healthy behaviors. The management of addictive behaviors should therefore be encouraged during HCV treatment.

Keywords: Behavioral changes; Cannabis; HCV cure; HIV; Hepatitis C; Marijuana; Smoking; Sustained virological response.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Cited by

Depressive symptoms after hepatitis C cure and socio-behavioral correlates in aging people living with HIV (ANRS CO13 HEPAVIH).
Marcellin F, Brégigeon-Ronot S, Ramier C, Protopopescu C, Gilbert C, Di Beo V, Duvivier C, Bureau-Stoltmann M, Rosenthal E, Wittkop L, Salmon-Céron D, Carrieri P, Sogni P, Barré T; ANRS CO13 HEPAVIH Study Group; Scientific Committee; Clinical Centers (ward: participating physicians); Data collection; Management, statistical analyses. Marcellin F, et al. JHEP Rep. 2022 Oct 28;5(1):100614. doi: 10.1016/j.jhepr.2022.100614. eCollection 2023 Jan. JHEP Rep. 2022. PMID: 36466990 Free PMC article.

References

1. Sellier P, Hamet G, Brun A, Ponscarme D, De Castro N, Alexandre G, et al. Mortality of people living with HIV in Paris Area from 2011 to 2015. AIDS Res Hum Retroviruses. 2019;36(5):373–380. doi: 10.1089/aid.2019.0143. - DOI - PubMed
1. Nishijima T, Inaba Y, Kawasaki Y, Tsukada K, Teruya K, Kikuchi Y, et al. Mortality and causes of death in people living with HIV in the era of combination antiretroviral therapy compared with the general population in Japan. AIDS. 2020;34(6):913–921. doi: 10.1097/QAD.0000000000002498. - DOI - PMC - PubMed
1. Fontela C, Aguinaga A, Moreno-Iribas C, Repáraz J, Rivero M, Gracia M, et al. Trends and causes of mortality in a population-based cohort of HIV-infected adults in Spain: comparison with the general population. Sci Rep. 2020;10(1):8922. doi: 10.1038/s41598-020-65841-0. - DOI - PMC - PubMed
1. Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet. 2013;382(9903):1525–1533. doi: 10.1016/S0140-6736(13)61809-7. - DOI - PMC - PubMed
1. Das D, Pandya M. Recent advancement of direct-acting antiviral agents (DAAs) in Hepatitis C therapy. Mini Rev Med Chem. 2018;18(7):584–596. doi: 10.2174/1389557517666170913111930. - DOI - PubMed

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[1] Sellier P, Hamet G, Brun A, Ponscarme D, De Castro N, Alexandre G, et al. Mortality of people living with HIV in Paris Area from 2011 to 2015. AIDS Res Hum Retroviruses. 2019;36(5):373–380. doi: 10.1089/aid.2019.0143. - DOI - PubMed

[2] Sellier P, Hamet G, Brun A, Ponscarme D, De Castro N, Alexandre G, et al. Mortality of people living with HIV in Paris Area from 2011 to 2015. AIDS Res Hum Retroviruses. 2019;36(5):373–380. doi: 10.1089/aid.2019.0143. - DOI - PubMed

[3] Nishijima T, Inaba Y, Kawasaki Y, Tsukada K, Teruya K, Kikuchi Y, et al. Mortality and causes of death in people living with HIV in the era of combination antiretroviral therapy compared with the general population in Japan. AIDS. 2020;34(6):913–921. doi: 10.1097/QAD.0000000000002498. - DOI - PMC - PubMed

[4] Nishijima T, Inaba Y, Kawasaki Y, Tsukada K, Teruya K, Kikuchi Y, et al. Mortality and causes of death in people living with HIV in the era of combination antiretroviral therapy compared with the general population in Japan. AIDS. 2020;34(6):913–921. doi: 10.1097/QAD.0000000000002498. - DOI - PMC - PubMed

[5] Fontela C, Aguinaga A, Moreno-Iribas C, Repáraz J, Rivero M, Gracia M, et al. Trends and causes of mortality in a population-based cohort of HIV-infected adults in Spain: comparison with the general population. Sci Rep. 2020;10(1):8922. doi: 10.1038/s41598-020-65841-0. - DOI - PMC - PubMed

[6] Fontela C, Aguinaga A, Moreno-Iribas C, Repáraz J, Rivero M, Gracia M, et al. Trends and causes of mortality in a population-based cohort of HIV-infected adults in Spain: comparison with the general population. Sci Rep. 2020;10(1):8922. doi: 10.1038/s41598-020-65841-0. - DOI - PMC - PubMed

[7] Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet. 2013;382(9903):1525–1533. doi: 10.1016/S0140-6736(13)61809-7. - DOI - PMC - PubMed

[8] Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet. 2013;382(9903):1525–1533. doi: 10.1016/S0140-6736(13)61809-7. - DOI - PMC - PubMed

[9] Das D, Pandya M. Recent advancement of direct-acting antiviral agents (DAAs) in Hepatitis C therapy. Mini Rev Med Chem. 2018;18(7):584–596. doi: 10.2174/1389557517666170913111930. - DOI - PubMed

[10] Das D, Pandya M. Recent advancement of direct-acting antiviral agents (DAAs) in Hepatitis C therapy. Mini Rev Med Chem. 2018;18(7):584–596. doi: 10.2174/1389557517666170913111930. - DOI - PubMed

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HCV cure: an appropriate moment to reduce cannabis use in people living with HIV? (ANRS CO13 HEPAVIH data)

Collaborators

Affiliations

HCV cure: an appropriate moment to reduce cannabis use in people living with HIV? (ANRS CO13 HEPAVIH data)

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

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Abstract

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