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Comment
. 2022 Mar 15;7(1):88.
doi: 10.1038/s41392-022-00956-6.

A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues

Long Min  1 , Qiu Sun  2
Affiliations
Comment

A promising strategy against SARS-CoV-2: pyrimidine inhibitors synergize with nucleoside analogues

Long Min et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Q.S. is the editorial board member of Signal Transduction and Targeted Therapy, but she has not been involved in the process of the manuscript handling.

Figures

Fig. 1
Fig. 1
Pyrimidine biosynthesis inhibitors and antiviral nucleoside analogues synergistically inhibit SARS-CoV-2 replication in vitro and in vivo. The combining pyrimidine biosynthesis inhibitors with antiviral nucleoside analogues suggest a new clinical forward facing the emerging strains of SARS-CoV-2. Created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2.
    Schultz DC, Johnson RM, Ayyanathan K, Miller J, Whig K, Kamalia B, Dittmar M, Weston S, Hammond HL, Dillen C, Ardanuy J, Taylor L, Lee JS, Li M, Lee E, Shoffler C, Petucci C, Constant S, Ferrer M, Thaiss CA, Frieman MB, Cherry S. Schultz DC, et al. Nature. 2022 Apr;604(7904):134-140. doi: 10.1038/s41586-022-04482-x. Epub 2022 Feb 7. Nature. 2022. PMID: 35130559 Free PMC article.

References

    1. Schultz, D. C. et al. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature (2022). 10.1038/s41586-022-04482-x. - PMC - PubMed
    1. Geraghty, R. J., Aliota, M. T. & Bonnac, L. F. Broad-spectrum antiviral strategies and nucleoside analogues. Viruses13, 667 (2021). - PMC - PubMed
    1. Janes J, et al. The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis. Proc. Natl. Acad. Sci. USA. 2018;115:10750–10755. doi: 10.1073/pnas.1810137115. - DOI - PMC - PubMed
    1. Jayk Bernal A, et al. Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients. N. Engl. J. Med. 2022;386:509–520. doi: 10.1056/NEJMoa2116044. - DOI - PMC - PubMed
    1. Wiersinga WJ, et al. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. J. Am. Med. Assoc. 2020;324:782–793. doi: 10.1001/jama.2020.12839. - DOI - PubMed