Neutrophils: a roadblock for immunotherapy

Hina Mir¹, Shailesh Singh^{2

3}

Affiliations

¹ Department of Microbiology, Biochemistry, and Immunology; Cancer Health Equity Institute, Morehouse School of Medicine, Atlanta, GA, USA.
² Department of Microbiology, Biochemistry, and Immunology; Cancer Health Equity Institute, Morehouse School of Medicine, Atlanta, GA, USA. shsingh@msm.edu.
³ Cell and Molecular Biology Program, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA. shsingh@msm.edu.

PMID: 35292762
DOI: 10.1038/s41568-022-00464-3

Comment

Neutrophils: a roadblock for immunotherapy

Hina Mir et al. Nat Rev Cancer. 2022 Jul.

. 2022 Jul;22(7):378-379.

doi: 10.1038/s41568-022-00464-3.

Authors

Hina Mir¹, Shailesh Singh^{2

3}

Affiliations

¹ Department of Microbiology, Biochemistry, and Immunology; Cancer Health Equity Institute, Morehouse School of Medicine, Atlanta, GA, USA.
² Department of Microbiology, Biochemistry, and Immunology; Cancer Health Equity Institute, Morehouse School of Medicine, Atlanta, GA, USA. shsingh@msm.edu.
³ Cell and Molecular Biology Program, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA. shsingh@msm.edu.

PMID: 35292762
DOI: 10.1038/s41568-022-00464-3

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CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Teijeira Á, Garasa S, Gato M, Alfaro C, Migueliz I, Cirella A, de Andrea C, Ochoa MC, Otano I, Etxeberria I, Andueza MP, Nieto CP, Resano L, Azpilikueta A, Allegretti M, de Pizzol M, Ponz-Sarvisé M, Rouzaut A, Sanmamed MF, Schalper K, Carleton M, Mellado M, Rodriguez-Ruiz ME, Berraondo P, Perez-Gracia JL, Melero I. Teijeira Á, et al. Immunity. 2020 May 19;52(5):856-871.e8. doi: 10.1016/j.immuni.2020.03.001. Epub 2020 Apr 13. Immunity. 2020. PMID: 32289253

References

Original article

1. Teijeira, A. et al. CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity. Immunity 52, 856–871 (2020) - DOI

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Neutrophils: a roadblock for immunotherapy

Affiliations

Neutrophils: a roadblock for immunotherapy

Authors

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Original article

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