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. 2022 Aug;88(8):3903-3910.
doi: 10.1111/bcp.15300. Epub 2022 Mar 22.

Are patients living far from hospital at higher risk of late adjuvant chemotherapy for colon cancer?

Thomas Vermeulin  1   2   3 , Hana Lahbib  2 , Mélodie Lucas  2   4 , Pierre Czernichow  2 , Florence Jusot  3 , Frédéric Di Fiore  5   6 , Véronique Merle  2   7
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Free article

Are patients living far from hospital at higher risk of late adjuvant chemotherapy for colon cancer?

Thomas Vermeulin et al. Br J Clin Pharmacol. 2022 Aug.
Free article

Abstract

Aims: Late adjuvant chemotherapy (aCT) administration after colectomy (>56 d) is known to be associated with impaired prognosis. We aim to identify risk factors associated with late aCT, especially the travel time between patients' home and hospital.

Methods: We performed a retrospective monocentre cohort study. Patients included had a colectomy for a stage III or high risk stage II colon cancer between 2009 and 2015 performed at a French university hospital. Risk factors for late aCT were identified using a fractional polynomial logistic regression.

Results: Ninety-four patients were included. The risk of late aCT was associated with travel time length, emergent colectomy, the need for scheduled care before aCT, and length of time between colectomy and postoperative multidisciplinary meeting advising aCT.

Conclusion: Our study suggests that, in patients with colon cancer, factors unrelated to disease severity and complexity could be associated with a higher risk of late aCT.

Keywords: adjuvant chemotherapy; colonic neoplasms; health services accessibility; time to treatment.

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References

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