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. 2022 Mar 14;48(1):e20220055.
doi: 10.36416/1806-3756/e20220055.

Why should noninferiority clinical trials be performed?

[Article in English, Portuguese]
Patricio Maskin  1   2 , Juliana Carvalho Ferreira  1   3 , Cecilia María Patino  1   4
Affiliations

Why should noninferiority clinical trials be performed?

[Article in English, Portuguese]
Patricio Maskin et al. J Bras Pneumol. .
No abstract available

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Figures

Figure 1
Figure 1. The figure shows possible result scenarios of a noninferiority clinical trial. The mean between-group differences (black circles) and respective 95% CIs (black error bars) for three potential scenarios comparing the new intervention with the active control are shown. The null hypothesis is that the difference between the new intervention and the active control is beyond the noninferiority margin, shown in the shadowed area. In our example (in red), the lower bound of the 95% CI is within the noninferiority margin; therefore, the null hypothesis is rejected and noninferiority can be claimed.
See this image and copyright information in PMC

References

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