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. 2022 Apr 21;386(16):1579-1580.
doi: 10.1056/NEJMc2201849. Epub 2022 Mar 16.

Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants

Jingyou Yu  1 , Ai-Ris Y Collier  1 , Marjorie Rowe  1 , Fatima Mardas  1 , John D Ventura  1 , Huahua Wan  1 , Jessica Miller  1 , Olivia Powers  1 , Benjamin Chung  1 , Mazuba Siamatu  1 , Nicole P Hachmann  1 , Nehalee Surve  1 , Felix Nampanya  1 , Abishek Chandrashekar  1 , Dan H Barouch  1
Affiliations

Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants

Jingyou Yu et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Mutations of Omicron BA.1 and BA.2 Sublineages and Neutralizing Antibody Responses.
Panel A shows the mutations of the omicron BA.1 and BA.2 sublineages in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Panel B shows neutralizing antibody titers that were measured by a luciferase-based pseudovirus neutralization assay in serum samples that were obtained from 24 persons who had been vaccinated and boosted. Titers were measured 2 weeks after the initial BNT162b2 vaccination (prime), before the third dose (booster) of the BNT162b2 vaccine (i.e., 6 months after the initial vaccination), and 2 weeks after the booster. Panel C shows neutralizing antibody titers that were measured in serum samples obtained from 8 persons with a history of SARS-CoV-2 infection, of whom 7 had been vaccinated. Titers were measured at a median of 14 days after the diagnosis of SARS-CoV-2 infection, presumably with BA.1. The person with no detectable neutralizing antibody titers was unvaccinated; the serum sample was obtained 4 days after diagnosis, and the person was hospitalized with severe coronavirus disease 2019 (Covid-19) pneumonia. In Panels B and C, neutralizing antibody responses against the SARS-CoV-2 WA1/2020 strain (WA) and the omicron BA.1 and BA.2 variants were evaluated. Median titers (horizontal gray lines) are presented, as well as the median titer values. Dots indicate individual samples. The horizontal dashed lines along the x axes indicate the limit of detection. FP denotes fusion peptide, HR1 heptad repeat 1, HR2 heptad repeat 2, NTD N-terminal domain, RBD receptor-binding domain, RBM receptor-binding motif, SD1 subdomain 1, and SD2 subdomain 2.
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References

    1. Viana R, Moyo S, Amoako DG, et al. Rapid epidemic expansion of the SARS-CoV-2 omicron variant in southern Africa. Nature 2022. January 7 (Epub ahead of print). - PMC - PubMed
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    1. Schmidt F, Muecksch F, Weisblum Y, et al. Plasma neutralization of the SARS-CoV-2 omicron variant. N Engl J Med 2022;386:599-601. - PMC - PubMed
    1. Liu L, Iketani S, Guo Y, et al. Striking antibody evasion manifested by the omicron variant of SARS-CoV-2. Nature 2022;602:676-681. - PubMed
    1. Polack FP, Thomas SJ, Kitchin N, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med 2020;383:2603-2615. - PMC - PubMed

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