Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec 13:3:753316.
doi: 10.3389/ftox.2021.753316. eCollection 2021.

Radiolabeling of Nanomaterials: Advantages and Challenges

Wanqin Dai  1   2   3 , Junzhe Zhang  4   5 , Yun Wang  1   2   3 , Chunlei Jiao  1   2   3 , Zhuda Song  1   2   3 , Yuhui Ma  1   2 , Yayun Ding  1   2 , Zhiyong Zhang  1   2   3 , Xiao He  1   2
Affiliations
Review

Radiolabeling of Nanomaterials: Advantages and Challenges

Wanqin Dai et al. Front Toxicol. .

Abstract

Quantifying the distribution of nanomaterials in complex samples is of great significance to the toxicological research of nanomaterials as well as their clinical applications. Radiotracer technology is a powerful tool for biological and environmental tracing of nanomaterials because it has the advantages of high sensitivity and high reliability, and can be matched with some spatially resolved technologies for non-invasive, real-time detection. However, the radiolabeling operation of nanomaterials is relatively complicated, and fundamental studies on how to optimize the experimental procedures for the best radiolabeling of nanomaterials are still needed. This minireview looks back into the methods of radiolabeling of nanomaterials in previous work, and highlights the superiority of the "last-step" labeling strategy. At the same time, the problems existing in the stability test of radiolabeling and the suggestions for further improvement are also addressed.

Keywords: derivatization strategy; in vivo stability; incorporation strategy; nanomaterials; radiolabeling; radiotracer technique.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer XC declared a shared affiliation, with no collaboration, with all of the authors to the handling editor at the time of the review.

Figures

FIGURE 1
FIGURE 1
Schematic diagrams for different types of radiometal detachment from NMs in vivo, especially at low pH milieu. (A), reasons for the detachment after chelator-based radiolabeling: (i) compromised chelation; (ii) failed conjugation; (iii) weak bond between NMs and radiometal; (iv) decomposition of the NMs. (B), reasons for the detachment after chemical adsorption radiolabeling: (i) desorption due to proton competition; (ii) carboxyl group protonation.
See this image and copyright information in PMC

References

    1. Abdollah M. R. A., Carter T. J., Jones C., Kalber T. L., Rajkumar V., Tolner B., et al. (2018). Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles. ACS Nano 12 (2), 1156–1169. 10.1021/acsnano.7b06734 - DOI - PubMed
    1. Antsiferova A. A., Buzulukov Y. P., Demin V. A., Demin V. F., Rogatkin D. A., Petritskaya E. N., et al. (2015). Radiotracer Methods and Neutron Activation Analysis for the Investigation of Nanoparticle Biokinetics in Living Organisms. Nanotechnol Russ. 10 (1), 100–108. 10.1134/s1995078015010024 - DOI
    1. Bouchard L.-S., Anwar M. S., Liu G. L., Hann B., Xie Z. H., Gray J. W., et al. (2009). Picomolar Sensitivity MRI and Photoacoustic Imaging of Cobalt Nanoparticles. Proc. Natl. Acad. Sci. 106 (11), 4085–4089. 10.1073/pnas.0813019106 - DOI - PMC - PubMed
    1. Cai H., Ma Y., Wu Z., Ding Y., Zhang P., He X., et al. (2016). Protein corona Influences Liver Accumulation and Hepatotoxicity of Gold Nanorods. NanoImpact 3-4, 40–46. 10.1016/j.impact.2016.09.005 - DOI
    1. Chakravarty R., Chakraborty S., Guleria A., Shukla R., Kumar C., Vimalnath Nair K. V., et al. (2018). Facile One-Pot Synthesis of Intrinsically Radiolabeled and Cyclic rgd Conjugated 199au Nanoparticles for Potential use in Nanoscale Brachytherapy. Ind. Eng. Chem. Res. 57 (43), 14337–14346. 10.1021/acs.iecr.8b02526 - DOI

LinkOut - more resources